BTG1
From Wikipedia, the free encyclopedia
| B-cell translocation gene 1, anti-proliferative | |||||||||||||
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| Identifiers | |||||||||||||
| Symbol | BTG1 | ||||||||||||
| External IDs | OMIM: 109580 MGI: 88215 HomoloGene: 37521 GeneCards: BTG1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 694 | 12226 | |||||||||||
| Ensembl | ENSG00000133639 | ENSMUSG00000036478 | |||||||||||
| UniProt | P62324 | P62325 | |||||||||||
| RefSeq (mRNA) | NM_001731 | NM_007569 | |||||||||||
| RefSeq (protein) | NP_001722 | NP_031595 | |||||||||||
| Location (UCSC) | Chr 12: 92.54 – 92.54 Mb | Chr 10: 96.62 – 96.62 Mb | |||||||||||
| PubMed search | |||||||||||||
Protein BTG1 is a protein that in humans is encoded by the BTG1 gene.[1][2]
The BTG1 gene locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. It negatively regulates cell proliferation.[2]
Interactions
BTG1 has been shown to interact with CNOT7,[3][4] HOXB9,[5] PRMT1[6][7] and CNOT8.[4][8]
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[9][10]
References
- ↑ Iwai K, Hirata K, Ishida T, Takeuchi S, Hirase T, Rikitake Y, Kojima Y, Inoue N, Kawashima S, Yokoyama M (March 2004). "An anti-proliferative gene BTG1 regulates angiogenesis in vitro". Biochem Biophys Res Commun 316 (3): 628–35. doi:10.1016/j.bbrc.2004.02.095. PMID 15033446.
- ↑ 2.0 2.1 "Entrez Gene: BTG1 B-cell translocation gene 1, anti-proliferative".
- ↑ Bogdan, J A; Adams-Burton C, Pedicord D L, Sukovich D A, Benfield P A, Corjay M H, Stoltenborg J K, Dicker I B (December 1998). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1". Biochem. J. 336 (ENGLAND). ( Pt 2): 471–81. ISSN 0264-6021. PMC 1219893. PMID 9820826.
- ↑ 4.0 4.1 Prévôt, D; Morel A P, Voeltzel T, Rostan M C, Rimokh R, Magaud J P, Corbo L (March 2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway". J. Biol. Chem. (United States) 276 (13): 9640–8. doi:10.1074/jbc.M008201200. ISSN 0021-9258. PMID 11136725.
- ↑ Prévôt, D; Voeltzel T, Birot A M, Morel A P, Rostan M C, Magaud J P, Corbo L (January 2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation". J. Biol. Chem. (United States) 275 (1): 147–53. doi:10.1074/jbc.275.1.147. ISSN 0021-9258. PMID 10617598.
- ↑ Lin, W J; Gary J D, Yang M C, Clarke S, Herschman H R (June 1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase". J. Biol. Chem. (United States) 271 (25): 15034–44. doi:10.1074/jbc.271.25.15034. ISSN 0021-9258. PMID 8663146.
- ↑ Berthet, Cyril; Guéhenneux Fabienne, Revol Valérie, Samarut Christiane, Lukaszewicz Agnès, Dehay Colette, Dumontet Charles, Magaud Jean-Pierre, Rouault Jean-Pierre (January 2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects". Genes Cells (England) 7 (1): 29–39. doi:10.1046/j.1356-9597.2001.00497.x. ISSN 1356-9597. PMID 11856371.
- ↑ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ↑ Morin, Ryan D.; Mendez-Lago, Maria; Mungall, Andrew J.; Goya, Rodrigo; Mungall, Karen L.; Corbett, Richard D.; Johnson, Nathalie A.; Severson, Tesa M.; Chiu, Readman; Field, Matthew; Jackman, Shaun; Krzywinski, Martin; Scott, David W.; Trinh, Diane L.; Tamura-Wells, Jessica; Li, Sa; Firme, Marlo R.; Rogic, Sanja; Griffith, Malachi; Chan, Susanna; Yakovenko, Oleksandr; Meyer, Irmtraud M.; Zhao, Eric Y.; Smailus, Duane; Moksa, Michelle; Chittaranjan, Suganthi; Rimsza, Lisa; Brooks-Wilson, Angela; Spinelli, John J.; Ben-Neriah, Susana; Meissner, Barbara; Woolcock, Bruce; Boyle, Merrill; McDonald, Helen; Tam, Angela; Zhao, Yongjun; Delaney, Allen; Zeng, Thomas; Tse, Kane; Butterfield, Yaron; Birol, Inanç; Holt, Rob; Schein, Jacqueline; Horsman, Douglas E.; Moore, Richard; Jones, Steven J. M.; Connors, Joseph M.; Hirst, Martin; Gascoyne, Randy D.; Marra, Marco A. (2011). "Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma". Nature 476 (7360): 298–303. doi:10.1038/nature10351. ISSN 0028-0836. PMC 3210554. PMID 21796119.
- ↑ Lohr, JG; Stojanov, P, Lawrence, MS, Auclair, D, Chapuy, B, Sougnez, C, Cruz-Gordillo, P, Knoechel, B, Asmann, YW, Slager, SL, Novak, AJ, Dogan, A, Ansell, SM, Link, BK, Zou, L, Gould, J, Saksena, G, Stransky, N, Rangel-Escareño, C, Fernandez-Lopez, JC, Hidalgo-Miranda, A, Melendez-Zajgla, J, Hernández-Lemus, E, Schwarz-Cruz Y Celis, A, Imaz-Rosshandler, I, Ojesina, AI, Jung, J, Pedamallu, CS, Lander, ES, Habermann, TM, Cerhan, JR, Shipp, MA, Getz, G, Golub, TR (2012-02-17). "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing.". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. doi:10.1073/pnas.1121343109. PMC 3309757. PMID 22343534.
Further reading
- Rouault JP, Rimokh R, Tessa C, et al. (1992). "BTG1, a member of a new family of antiproliferative genes.". EMBO J. 11 (4): 1663–70. PMC 556617. PMID 1373383.
- Rimokh R, Rouault JP, Wahbi K, et al. (1991). "A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.". Genes Chromosomes Cancer 3 (1): 24–36. doi:10.1002/gcc.2870030106. PMID 2069907.
- Lin WJ, Gary JD, Yang MC, et al. (1996). "The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase.". J. Biol. Chem. 271 (25): 15034–44. doi:10.1074/jbc.271.25.15034. PMID 8663146.
- Corjay MH, Kearney MA, Munzer DA, et al. (1998). "Antiproliferative gene BTG1 is highly expressed in apoptotic cells in macrophage-rich areas of advanced lesions in Watanabe heritable hyperlipidemic rabbit and human.". Lab. Invest. 78 (7): 847–58. PMID 9690562.
- Bogdan JA, Adams-Burton C, Pedicord DL, et al. (1999). "Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.". Biochem. J. 336. ( Pt 2): 471–81. PMC 1219893. PMID 9820826.
- Prévôt D, Voeltzel T, Birot AM, et al. (2000). "The leukemia-associated protein Btg1 and the p53-regulated protein Btg2 interact with the homeoprotein Hoxb9 and enhance its transcriptional activation.". J. Biol. Chem. 275 (1): 147–53. doi:10.1074/jbc.275.1.147. PMID 10617598.
- Prévôt D, Morel AP, Voeltzel T, et al. (2001). "Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.". J. Biol. Chem. 276 (13): 9640–8. doi:10.1074/jbc.M008201200. PMID 11136725.
- Rodier A, Rochard P, Berthet C, et al. (2001). "Identification of functional domains involved in BTG1 cell localization.". Oncogene 20 (21): 2691–703. doi:10.1038/sj.onc.1204398. PMID 11420681.
- Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex.". Jpn. J. Cancer Res. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMID 11429045.
- Berthet C, Guéhenneux F, Revol V, et al. (2002). "Interaction of PRMT1 with BTG/TOB proteins in cell signalling: molecular analysis and functional aspects.". Genes Cells 7 (1): 29–39. doi:10.1046/j.1356-9597.2001.00497.x. PMID 11856371.
- Sasajima H, Nakagawa K, Yokosawa H (2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system.". Eur. J. Biochem. 269 (14): 3596–604. doi:10.1046/j.1432-1033.2002.03052.x. PMID 12135500.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Bakker WJ, Blázquez-Domingo M, Kolbus A, et al. (2004). "FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1.". J. Cell Biol. 164 (2): 175–84. doi:10.1083/jcb.200307056. PMC 2172323. PMID 14734530.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Busson M, Carazo A, Seyer P, et al. (2005). "Coactivation of nuclear receptors and myogenic factors induces the major BTG1 influence on muscle differentiation.". Oncogene 24 (10): 1698–710. doi:10.1038/sj.onc.1208373. PMID 15674337.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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