BTBD1
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| BTB (POZ) domain containing 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | BTBD1; C15orf1; NS5ATP8 | ||||||||||||
| External IDs | OMIM: 608530 MGI: 1933765 HomoloGene: 23529 GeneCards: BTBD1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 53339 | 83962 | |||||||||||
| Ensembl | ENSG00000064726 | ENSMUSG00000025103 | |||||||||||
| UniProt | Q9H0C5 | P58544 | |||||||||||
| RefSeq (mRNA) | NM_001011885 | NM_146193 | |||||||||||
| RefSeq (protein) | NP_001011885 | NP_666305 | |||||||||||
| Location (UCSC) | Chr 15: 83.69 – 83.74 Mb | Chr 7: 81.79 – 81.83 Mb | |||||||||||
| PubMed search | |||||||||||||
BTB/POZ domain-containing protein 1 is a protein that in humans is encoded by the BTBD1 gene.[1]
The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. Alternative splicing results in multiple transcript variants encoding different isoforms.[1]
Interactions
BTBD1 has been shown to interact with TOP1.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: BTBD1 BTB (POZ) domain containing 1".
- ↑ Xu, Lixin; Yang Lihong, Hashimoto Keiko, Anderson Melvin, Kohlhagen Glenda, Pommier Yves, D'Arpa Peter (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics (England) 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Carim-Todd L, Sumoy L, Andreu N et al. (2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene 262 (1–2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693.
- Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
- Xu L, Yang L, Hashimoto K et al. (2003). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781. PMID 11818025.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Xu L, Yang L, Moitra PK et al. (2003). "BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta". Exp. Cell Res. 288 (1): 84–93. doi:10.1016/S0014-4827(03)00187-3. PMID 12878161.
- Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Pisani DF, Cabane C, Derijard B, Dechesne CA (2005). "The topoisomerase 1-interacting protein BTBD1 is essential for muscle cell differentiation". Cell Death Differ. 11 (11): 1157–65. doi:10.1038/sj.cdd.4401479. PMID 15486563.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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