BCL2L11
From Wikipedia, the free encyclopedia
Bcl-2-like protein 11 is a protein that in humans is encoded by the BCL2L11 gene.[1][2]
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1 (FoxO3a), which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.[3]
Interactions
BCL2L11 has been shown to interact with DYNLL1,[4][5] MCL1,[1][6][7] BCL2-like 1,[1][2][6][8] BCL2L2[1][2] and Bcl-2.[1][2][6]
See also
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Hsu SY, Lin P, Hsueh AJ (November 1998). "BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members". Mol Endocrinol 12 (9): 1432–40. doi:10.1210/me.12.9.1432. PMID 9731710.
- ↑ 2.0 2.1 2.2 2.3 O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC (February 1998). "Bim: a novel member of the Bcl-2 family that promotes apoptosis". EMBO J 17 (2): 384–95. doi:10.1093/emboj/17.2.384. PMC 1170389. PMID 9430630.
- ↑ "Entrez Gene: BCL2L11 BCL2-like 11 (apoptosis facilitator)".
- ↑ Day, Catherine L; Puthalakath Hamsa, Skea Gretchen, Strasser Andreas, Barsukov Igor, Lian Lu-Yun, Huang David C S, Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. (England) 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
- ↑ Vadlamudi, Ratna K; Bagheri-Yarmand Rozita, Yang Zhibo, Balasenthil Seetharaman, Nguyen Diep, Sahin Aysegul A, den Hollander Petra, Kumar Rakesh (June 2004). "Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes". Cancer Cell (United States) 5 (6): 575–85. doi:10.1016/j.ccr.2004.05.022. ISSN 1535-6108. PMID 15193260.
- ↑ 6.0 6.1 6.2 Chen, Lin; Willis Simon N, Wei Andrew, Smith Brian J, Fletcher Jamie I, Hinds Mark G, Colman Peter M, Day Catherine L, Adams Jerry M, Huang David C S (February 2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell (United States) 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. ISSN 1097-2765. PMID 15694340.
- ↑ Bae, J; Leo C P, Hsu S Y, Hsueh A J (August 2000). "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. (UNITED STATES) 275 (33): 25255–61. doi:10.1074/jbc.M909826199. ISSN 0021-9258. PMID 10837489.
- ↑ Whitfield, Jonathan; Harada Kokichi, Bardelle Catherine, Staddon James M (November 2003). "High-throughput methods to detect dimerization of Bcl-2 family proteins". Anal. Biochem. (United States) 322 (2): 170–8. doi:10.1016/j.ab.2003.07.014. ISSN 0003-2697. PMID 14596824.
Further reading
- Wang K, Yin XM, Chao DT, et al. (1996). "BID: a novel BH3 domain-only death agonist". Genes Dev. 10 (22): 2859–69. doi:10.1101/gad.10.22.2859. PMID 8918887.
- Zha J, Harada H, Yang E, et al. (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell 87 (4): 619–28. doi:10.1016/S0092-8674(00)81382-3. PMID 8929531.
- Huang DC, Adams JM, Cory S (1998). "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4". EMBO J. 17 (4): 1029–39. doi:10.1093/emboj/17.4.1029. PMC 1170452. PMID 9463381.
- Puthalakath H, Huang DC, O'Reilly LA, et al. (1999). "The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex". Mol. Cell 3 (3): 287–96. doi:10.1016/S1097-2765(00)80456-6. PMID 10198631.
- Ohi N, Tokunaga A, Tsunoda H, et al. (1999). "A novel adenovirus E1B19K-binding protein B5 inhibits apoptosis induced by Nip3 by forming a heterodimer through the C-terminal hydrophobic region". Cell Death Differ. 6 (4): 314–25. doi:10.1038/sj.cdd.4400493. PMID 10381623.
- Bouillet P, Metcalf D, Huang DC, et al. (1999). "Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity". Science 286 (5445): 1735–8. doi:10.1126/science.286.5445.1735. PMID 10576740.
- Bae J, Leo CP, Hsu SY, Hsueh AJ (2000). "MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain". J. Biol. Chem. 275 (33): 25255–61. doi:10.1074/jbc.M909826199. PMID 10837489.
- Dijkers PF, Medema RH, Lammers JW, et al. (2000). "Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1". Curr. Biol. 10 (19): 1201–4. doi:10.1016/S0960-9822(00)00728-4. PMID 11050388.
- Bouillet P, Zhang LC, Huang DC, et al. (2001). "Gene structure alternative splicing, and chromosomal localization of pro-apoptotic Bcl-2 relative Bim". Mamm. Genome 12 (2): 163–8. doi:10.1007/s003350010242. PMID 11210187.
- Putcha GV, Moulder KL, Golden JP, et al. (2001). "Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis". Neuron 29 (3): 615–28. doi:10.1016/S0896-6273(01)00238-0. PMID 11301022.
- Murray S, Halford S, Ebenezer ND, et al. (2001). "Assignment of BCL2L11 to human chromosome band 2p13 with somatic cell and radiation hybrids". Cytogenet. Cell Genet. 92 (3–4): 353. doi:10.1159/000056930. PMID 11435715.
- Cheng EH, Wei MC, Weiler S, et al. (2001). "BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis". Mol. Cell 8 (3): 705–11. doi:10.1016/S1097-2765(01)00320-3. PMID 11583631.
- U M, Miyashita T, Shikama Y, et al. (2002). "Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family". FEBS Lett. 509 (1): 135–41. doi:10.1016/S0014-5793(01)03145-3. PMID 11734221.
- Bouillet P, Purton JF, Godfrey DI, et al. (2002). "BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes". Nature 415 (6874): 922–6. doi:10.1038/415922a. PMID 11859372.
- Marani M, Tenev T, Hancock D, et al. (2002). "Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis". Mol. Cell. Biol. 22 (11): 3577–89. doi:10.1128/MCB.22.11.3577-3589.2002. PMC 133811. PMID 11997495.
- Liu JW, Chandra D, Tang SH, et al. (2002). "Identification and characterization of Bimgamma, a novel proapoptotic BH3-only splice variant of Bim". Cancer Res. 62 (10): 2976–81. PMID 12019181.
- Terradillos O, Montessuit S, Huang DC, Martinou JC (2002). "Direct addition of BimL to mitochondria does not lead to cytochrome c release". FEBS Lett. 522 (1–3): 29–34. doi:10.1016/S0014-5793(02)02871-5. PMID 12095614.
- Sugiyama T, Shimizu S, Matsuoka Y, et al. (2002). "Activation of mitochondrial voltage-dependent anion channel by apro-apoptotic BH3-only protein Bim". Oncogene 21 (32): 4944–56. doi:10.1038/sj.onc.1205621. PMID 12118373.
External links
- BCL2L11 human gene location in the UCSC Genome Browser.
- BCL2L11 human gene details in the UCSC Genome Browser.
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