Aspartoacylase

From Wikipedia, the free encyclopedia
aspartoacylase (Canavan disease)
Identifiers
Symbol ASPA
Entrez 443
HUGO 756
OMIM 608034
RefSeq NM_000049
UniProt P45381
Other data
Locus Chr. 17 p13-ter
aspartoacylase (aminocyclase) 3
Identifiers
Symbol ACY3
Entrez 91703
HUGO 24104
RefSeq NM_080658
UniProt Q96HD9
Other data
Locus Chr. 11 q13

Aspartoacylase (EC 3.5.1.15, aminoacylase II, N-acetylaspartate amidohydrolase, acetyl-aspartic deaminase, acylase II) is a hydrolase enzyme with system name N-acyl-L-aspartate amidohydrolase.,[1][2] which breaks down N-acetylaspartate. A deficiency is associated with Canavan disease.This enzyme catalyses the following chemical reaction

N-acyl-L-aspartate + H2O \rightleftharpoons a carboxylate + L-aspartate

References

  1. ↑ Birnbaum, S.M. (1955). "Aminoacylase. Amino acid aminoacylases I and II from hog kidney". Methods Enzymol. 2: 115–119. 
  2. ↑ Birnbaum, S.M., Levintow, L., Kingsley, R.B. and Greenstein, J.P. (1952). "Specificity of amino acid acylases". J. Biol. Chem. 194: 455–470. PMID 14927637. 

External links

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)
3.5.1: Linear amides /
Amidohydrolases
3.5.2: Cyclic amides/
Amidohydrolases
3.5.3: Linear amidines/
Ureohydrolases
3.5.4: Cyclic amidines/
Aminohydrolases
3.5.5: Nitriles/
Aminohydrolases
3.5.99: Other
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