ARHGAP24

From Wikipedia, the free encyclopedia

Rho GTPase activating protein 24

Identifiers

ARHGAP24; FILGAP; RC-GAP72; RCGAP72; p73; p73RhoGAP

External IDs

OMIM: 610586 MGI: 1922647 HomoloGene: 32754 GeneCards: ARHGAP24 Gene

Gene Ontology
Molecular function	• GTPase activator activity • protein binding • phospholipid binding
Cellular component	• cytoplasm • cytosol • cytoskeleton • plasma membrane • focal adhesion • cell projection
Biological process	• angiogenesis • small GTPase mediated signal transduction • cell differentiation • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000138639

ENSMUSG00000057315

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
86.4 – 86.92 Mb

Chr 5:
102.48 – 102.9 Mb

PubMed search

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene.^[1]^[2]^[3]

References

↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Katoh M, Katoh M (Jul 2004). "Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico". Int J Mol Med 14 (2): 333–8. PMID 15254788.
↑ "Entrez Gene: ARHGAP24 Rho GTPase activating protein 24".

Further reading

"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lee SY, Obata Y, Yoshida M et al. (2003). "Immunomic analysis of human sarcoma". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2651–2656. doi:10.1073/pnas.0437972100. PMC 151395. PMID 12601173.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Su ZJ, Hahn CN, Goodall GJ et al. (2004). "A vascular cell-restricted RhoGAP, p73RhoGAP, is a key regulator of angiogenesis". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12212–12217. doi:10.1073/pnas.0404631101. PMC 514459. PMID 15302923.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lavelin I, Geiger B (2005). "Characterization of a novel GTPase-activating protein associated with focal adhesions and the actin cytoskeleton". J. Biol. Chem. 280 (8): 7178–7185. doi:10.1074/jbc.M411990200. PMID 15611138.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ohta Y, Hartwig JH, Stossel TP (2006). "FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling". Nat. Cell Biol. 8 (8): 803–814. doi:10.1038/ncb1437. PMID 16862148.

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