7-Methylguanosine

From Wikipedia, the free encyclopedia

7-Methylguanosine

IUPAC name 7-Methylguanosine
Other names N7-Methylguanosine; 2-Amino-1,6-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosylpurinium
Identifiers
Abbreviations	m7G; m⁷G
CAS number	20244-86-4^N
PubChem	445404
ChemSpider	393054^Y
ChEBI	CHEBI:20794^Y
Jmol-3D images	{{#if:O=C3/N=C(/N)Nc1c3n(c[n+]1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)C\|Image 1
SMILES O=C3/N=C(/N)Nc1c3n(c[n+]1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)C
InChI InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1^Y Key: OGHAROSJZRTIOK-KQYNXXCUSA-O^Y InChI=1/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1 Key: OGHAROSJZRTIOK-UJMNIJGGBX
Properties
Molecular formula	C₁₁H₁₆N₅O₅
Molar mass	298.28 g mol⁻¹
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

7-Methylguanosine (m7G) is a modified purine nucleobase. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. It also plays a role in RNA as blocking group at its 5´-end. ^[1]

References

↑ Reynaud, C; Bruno, C; Boullanger, P; Grange, J; Barbesti, S; Niveleau, A (1992). "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies". Cancer letters 61 (3): 255–62. PMID 1739950.

External links

Metabocard for 7-Methylguanosine (HMDB01107), Human Metabolome Database, University of Alberta

This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.