7-Chlorokynurenic acid

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7-Chlorokynurenic acid

IUPAC name 7-Chloro-4-hydroxy-2-quinolinecarboxylic acid
Other names 7-CTKA
Identifiers
	ChemSpider	1813
Jmol-3D images	Image 1
SMILES C1=CC2=C(C=C1Cl)N=C(C=C2O)C(=O)O
InChI InChI=1S/C10H6ClNO3/c11-5-1-2-6-7(3-5)12-8(10(14)15)4-9(6)13/h1-4H,(H,12,13)(H,14,15) Key: UAWVRVFHMOSAPU-UHFFFAOYSA-N
Properties
Molecular formula	C₁₀H₆ClNO₃
Molar mass	223.61 g mol⁻¹
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

7-Chlorokynurenic acid (7-CTKA) is a NMDA receptor antagonist with antidepressant activity in rats.^[1]^[2]

References

↑ Kemp, JA; Foster, AC; Leeson, PD; Priestley, T; Tridgett, R; Iversen, LL; Woodruff, GN (1988). "7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex". Proceedings of the National Academy of Sciences of the United States of America 85 (17): 6547–6550. PMC 282010.
↑ Zhu, WL; Wang, SJ; Liu, MM; Shi, HS; Zhang, RX; Liu, JF; Ding, ZB; Lu, L (2013). "Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats". Journal of psychiatry & neuroscience : JPN 38 (5): 306–16. doi:10.1503/jpn.120228. PMC 3756114. PMID 23611177.

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