6,7-dihydropteridine reductase
| 6,7-dihydropteridine reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.5.1.34 | ||||||||
| CAS number | 9074-11-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a 6,7-dihydropteridine reductase (EC 1.5.1.34) is an enzyme that catalyzes the chemical reaction
- a 5,6,7,8-tetrahydropteridine + NAD(P)+
a 6,7-dihydropteridine + NAD(P)H + H+
The 3 substrates of this enzyme are 5,6,7,8-tetrahydropteridine, NAD+, and NADP+, whereas its 4 products are 6,7-dihydropteridine, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase. Other names in common use include 6,7-dihydropteridine:NAD(P)H oxidoreductase, DHPR, NAD(P)H:6,7-dihydropteridine oxidoreductase, NADH-dihydropteridine reductase, NADPH-dihydropteridine reductase, NADPH-specific dihydropteridine reductase, dihydropteridine (reduced nicotinamide adenine dinucleotide), reductase, dihydropteridine reductase, dihydropteridine reductase (NADH), and 5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase. This enzyme participates in folate biosynthesis.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1YKI, 1YLR, and 1YLU.
References
- Harano T (1972). "New diaphorases from Bombyx silkworm eggs. NADH/NADPH cytochrome c reductase activity mediated with 6,7-dimethyltetrahydropterin". Insect Biochem. 2 (8): 385–399. doi:10.1016/0020-1790(72)90019-4.
- Hasegawa H (Tokyo). "Dihydropteridine reductase from bovine liver. Purification, crystallization, and isolation of a binary complex with NADH". J. Biochem. (1): 169–77. PMID 191436.
- Kaufman S; Bridgers, WF; Eisenberg, F; Friedman, S (1962). "Phenylalanine hydroxylase". Methods Enzymol. 5: 809–816. PMID 14031389.
- Lind KE (1972). "Dihydropteridine reductase. Investigation of the specificity for quinoid dihydropteridine and the inhibition by 2,4-diaminopteridines". Eur. J. Biochem. 25 (3): 560–2. doi:10.1111/j.1432-1033.1972.tb01728.x. PMID 4402916.
- Nakanishi N, Hasegawa H, Watabe S (Tokyo). "A new enzyme, NADPH-dihydropteridine reductase in bovine liver". J. Biochem. (3): 681–5. PMID 16875.