4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
From Wikipedia, the free encyclopedia
| 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.17.7.1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
| |||||||||
In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) is an enzyme that catalyzes the chemical reaction
- (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide
2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol
The 3 substrates of this enzyme are (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP), water, and protein disulfide, whereas its two products are 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and protein dithiol.
This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating). This enzyme participates in biosynthesis of steroids.
References
- D, Rohdich F; Eisenreich, W; Adam, P; Amslinger, S; Kis, K; Bacher, A; Arigoni, D; Rohdich, F (2001). "Studies on the nonmevalonate pathway to terpenes: the role of the GcpE (IspG) protein". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14837–42. doi:10.1073/pnas.201399298. PMC 64945. PMID 11752431.
This article is issued from Wikipedia. The text is available under the Creative Commons Attribution/Share Alike; additional terms may apply for the media files.