3,4-Dihydroxyphenylacetaldehyde

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3,4-Dihydroxyphenylacetaldehyde
Identifiers
Abbreviations DOPAL
CAS number 5707-55-1 N
PubChem 119219
ChemSpider 106504 YesY
KEGG C04043 YesY
MeSH 3,4-dihydroxyphenylacetaldehyde
ChEBI CHEBI:27978 YesY
3DMet B00668
Jmol-3D images Image 1
Image 2
Properties
Molecular formula C8H8O3
Molar mass 152.15 g mol−1
Density 1.306 g/mL
Boiling point 351 °C; 664 °F; 624 K
Related compounds
Related 2-phenyl aldehydes Phenylacetaldehyde

Phenylglyoxal

 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is a metabolite of the neurotransmitter dopamine. DOPAL is an important precursor of the major brain metabolites of dopamine, 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxy-phenylacetic acid. DOPAL plays a role in Parkinson's disease.[2] DOPAL has been chemically synthesized.[3]

References

  1. "3,4-dihydroxyphenylacetaldehyde - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 24 June 2005. Identification and Related Records. Retrieved 13 October 2011. 
  2. Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ, Sharabi Y., "Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease," J Neurochem. 2013 Sep;126(5):591-603.
  3. Li, W., Spaziano, V.T., Burke, WJ., "Synthesis of a biochemicallly important aldehyde - 3,4-dihydroxyphenylacetaldehyde", Bio-Organic Chemistry, 26, 45-50, 1998.
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