Alpha-Hydroxyglutaric acid

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α-Hydroxyglutaric acid

IUPAC name 2-Hydroxypentanedioic acid
Other names 2-Hydroxyglutaric acid
Identifiers
CAS number	2889-31-8
PubChem	43
ChemSpider	42^Y
KEGG	C02630^Y
MeSH	Alpha-hydroxyglutarate
ChEBI	CHEBI:17084^Y
Jmol-3D images	Image 1 Image 2
SMILES C(CC(=O)O)C(C(=O)O)O O=C(O)C(O)CCC(=O)O
InChI InChI=1S/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10)^Y Key: HWXBTNAVRSUOJR-UHFFFAOYSA-N^Y InChI=1/C5H8O5/c6-3(5(9)10)1-2-4(7)8/h3,6H,1-2H2,(H,7,8)(H,9,10) Key: HWXBTNAVRSUOJR-UHFFFAOYAI
Properties
Molecular formula	C₅H₈O₅
Molar mass	148.11 g mol⁻¹
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

α-Hydroxyglutaric acid (2-hydroxyglutaric acid) is an alpha hydroxy acid. In humans the compound is formed by a hydroxyacid-oxoacid transhydrogenase whereas in bacteria is formed by a 2-hydroxyglutarate synthase. The compound can be converted to α-ketoglutaric acid through the action of a 2-hydroxyglutarate dehydrogenase which, in humans, are two enzymes called D2HGDH and L2HGDH. Deficiency in either of these two enzymes lead to a disease known as 2-hydroxyglutaric aciduria.

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