2-acylglycerol-3-phosphate O-acyltransferase

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2-acylglycerol-3-phosphate O-acyltransferase
Identifiers
EC number 2.3.1.52
CAS number 51901-17-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 2-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.52) is an enzyme that catalyzes the chemical reaction

acyl-CoA + 2-acyl-sn-glycerol 3-phosphate \rightleftharpoons CoA + 1,2-diacyl-sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycerol 3-phosphate, whereas its two products are CoA and 1,2-diacyl-sn-glycerol 3-phosphate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycerol 3-phosphate O-acyltransferase. This enzyme is also called 2-acylglycerophosphate acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

    • Yamashita S, Hosaka K, Numa S (1973). "Acyl-donor specificities of partially purified 1-acylglycerophosphate acyltransferase, 2-acylglycerophosphate acyltransferase and 1-acylglycerophosphorylcholine acyltransferase from rat-liver microsomes". Eur. J. Biochem. 38 (1): 25–31. doi:10.1111/j.1432-1033.1973.tb03028.x. PMID 4774123. 
    2.3.1: other than amino-acyl groups
    2.3.2: Aminoacyltransferases
    2.3.3: converted into alkyl on transfer
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