17Beta Hydroxysteroid dehydrogenase

From Wikipedia, the free encyclopedia
17β-Hydroxysteroid dehydrogenase
Identifiers
EC number 1.1.1.51
CAS number 9015-81-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Steroidogenesis. 17β-HSD visible at left.

17β-Hydroxysteroid dehydrogenases (EC 1.1.1.51, beta-hydroxy steroid dehydrogenase, 17-ketoreductase, 17beta-hydroxy steroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxy steroid dehydrogenase, 17β-HSD, 17-ketosteroid oxidoreductases, HSD17B, 17-ketosteroid reductases, 17-KSR), are a group of alcohol oxidoreductases which catalyse the dehydrogenation of 17-hydroxysteroids in steroidogenesis.[1][2][3][4][5] This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol, respectively.[6][7]

Note that the major reactions catalysed by 17β-HSD (e.g., the conversion of androstenedione to testosterone) are in fact hydrogenation (reduction) rather than dehydrogenation (oxidation) reactions.

Genes

Genes coding for 17β-HSD include:

Clinical significance

Isozyme 3 is responsible for 17-beta-hydroxysteroid dehydrogenase deficiency.

References

  1. ↑ Dahm, K. and Breuer, H. (1964). "Anreicherung einer 17β-hydroxysteroid:NAD(P)-oxydoreduktase aus der Nebenniere der Ratte". Hoppe-Seyler's Z. Physiol. Chem. 336: 63–68. PMID 14214322. 
  2. ↑ Lynn, W. S. and Brown, R. H. (1958). "The conversion of progesterone to androgens by testes". J. Biol. Chem. 232 (2): 1015–1030. PMID 13549484. 
  3. ↑ Marcus, P. I. and Talalay, P. (1956). "Induction and purification of α- and β-hydroxysteroid dehydrogenases". J. Biol. Chem. 218 (2): 661–674. PMID 13295221. 
  4. ↑ Schultz, R. M., Groman, F. V. and Engel, L. L. (1977). "3(17)β-Hydroxysteroid dehydrogenase of Pseudomonas testosteroni. A convenient purification and demonstration of multiple molecular forms". J. Biol. Chem. 252: 3775–3783. PMID 193845. 
  5. ↑ Talalay, P. and Dobson, M. M. (1953). "Purification and properties of a α-hydroxysteroid dehydrogenase". J. Biol. Chem. 205: 823–837. PMID 13129261. 
  6. ↑ Labrie, F.; Luu-The, V.; Lin. S. X. et al. (January 1997). "The key role of 17 beta-hydroxysteroid dehydrogenases in sex steroid biology". Steroids 62 (1): 148–58. doi:10.1016/S0039-128X(96)00174-2. PMID 9029730. 
  7. ↑ Charles G. D. Brook; Daniel Truong, M.D.; Peter Clayton; William Carroll, Rosalind Brown (22 September 2011). Brook's Clinical Pediatric Endocrinology. John Wiley & Sons. p. 288. ISBN 978-1-4443-1673-5. Retrieved 29 April 2012. 

External links

1.1.1: NAD/NADP acceptor
1.1.2: cytochrome acceptor
1.1.3: oxygen acceptor
1.1.4: disulfide as acceptor
1.1.5: quinone/similar acceptor
1.1.99: other acceptors
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Mevalonate pathway
To HMG-CoA
Ketogenesis
To Mevalonic acid
To DMAPP
Geranyl-
To cholesterol
To lanosterol
7-Dehydrocholesterol path
Desmosterol path
To Bile acids
Steroidogenesis
To pregnenolone
To corticosteroids
To sex hormones
To androgens
To estrogens
Other/ungrouped

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m (A16/C10), i (k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco (d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

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