1,2-Dichloropropane
| 1,2-Dichloropropane[1] | |
|---|---|
 | |
| 1,2-Dichloropropane | |
| Other names Propylene dichloride | |
| Identifiers | |
| CAS number | 78-87-5  |
| PubChem | 6564 |
| ChemSpider | 6316 |
| UNII | RRZ023OFWL |
| KEGG | C19034  |
| ChEMBL | CHEMBL44641 |
| Jmol-3D images | Image 1 |
| |
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| Properties | |
| Molecular formula | C3H6Cl2 |
| Molar mass | 112.99 g mol−1 |
| Appearance | Colorless liquid |
| Odor | like chloroform |
| Density | 1.156 g/cm3 |
| Melting point | −100 °C; −148 °F; 173 K |
| Boiling point | 95 to 96 °C; 203 to 205 °F; 368 to 369 K |
| Solubility in water | 0.26 g/100 mL (at 20 °C) |
| Hazards | |
| R-phrases | R11 R20/22 |
| S-phrases | S16 S24 |
| Flash point | 16 °C; 61 °F; 289 K |
| Autoignition temperature | 557 °C; 1,035 °F; 830 K |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) | |
| Infobox references | |
1,2-Dichloropropane is an organic compound classified as a chlorocarbon. It is a colorless, flammable liquid with a sweet odor. it is obtained as a byproduct of the production of epichlorohydrin, which is produced on a large scale.[2]
Uses
1,2-Dichloropropane is an intermediate in the production of perchloroethylene and other chlorinated chemicals.[2] It was once used as a soil fumigant, chemical intermediate, as well as an industrial solvent and was found in paint strippers, varnishes, and furniture finish removers but some of these uses have been discontinued.[3]
Carcinogenity
Following several cases of bile duct cancer among Japanese printing firm employees, an investigation by the Japanese Ministry of Health, Labour and Welfare concluded in March 2013 that these cases were likely due to the use of cleaning agents containing 1,2-dichloropropane. Thus, there is reasonable evidence that 1,2-dichloropropane may be a carcinogen.[4][5]
Data from animal studies show tumor growth in the liver and mammary glands.[6] Further animal studies involving inhalation toxicity data has caused the National Institute for Occupational Safety and Health to classify 1,2-dichloropropane as a carcinogen and IDLH.[7]
References
- ↑ 1,2-Dichloropropane at Sigma-Aldrich
- ↑ 2.0 2.1 Manfred Rossberg, Wilhelm Lendle, Gerhard Pfleiderer, Adolf Tögel, Eberhard-Ludwig Dreher, Ernst Langer, Heinz Rassaerts, Peter Kleinschmidt, Heinz Strack, Richard Cook, Uwe Beck, Karl-August Lipper, Theodore R. Torkelson, Eckhard Löser, Klaus K. Beutel, Trevor Mann “Chlorinated Hydrocarbons” in Ullmann's Encyclopedia of Industrial Chemistry 2006, Wiley-VCH, Weinheim. doi:10.1002/14356007.a06_233.pub2.
- ↑ ToxFAQs for 1,2-Dichloropropane
- ↑ Report by the Japanese Ministry of Health, Labour and Welfare
- ↑ Article in the Yomiuri Shinbun
- ↑ CDC - NIOSH Pocket Guide to Chemical Hazards
- ↑ Documentation for Immediately Dangerous To Life or Health Concentrations (IDLHs)