Alpha-v beta-3

αVβ3 is a type of integrin that is a receptor for vitronectin[1]. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore it is a receptor for phagocytosis on macrophages or dendritic cells. [2]

Inhibitors like etaracizumab may be used as antiangiogenics.

See also

References

  1. ^ Hermann, P; Armant, M; Brown, E; Rubio, M; Ishihara, H; Ulrich, D; Caspary, RG; Lindberg, FP et al. (1999). "The vitronectin receptor and its associated CD47 molecule mediates proinflammatory cytokine synthesis in human monocytes by interaction with soluble CD23". The Journal of cell biology 144 (4): 767–75. doi:10.1083/jcb.144.4.767. PMC 2132927. PMID 10037797. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132927. 
  2. ^ Yamaguchi, H; et al. (2008). "Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus". Journal of Leukocyte Biology. 
Alpha
A1 · A2 · A3 · A4 · A5 · A6 · A7 · A8 · A9 · A10 · A11 · AD · AE · AL · AM · AV · AX
Beta
B1 · B2 · B3 · B4 · B5 · B6 · B7 · B8
Dimers

Cytoadhesin receptor: Integrin alpha6beta4 · Glycoprotein IIb/IIIa (ITGA2B+ITGB3)

Fibrinogen receptor: Macrophage-1 antigen (CD11b+CD18)

Fibronectin receptor: Integrin alpha2beta1 · Integrin alpha4beta1 · Integrin alpha5beta1

Leukocyte-adhesion receptor: LFA-1 (CD11a+CD18) · Macrophage-1 antigen (CD11b+CD18) · Integrin alphaXbeta2 (CD11c+CD18)

Very late antigen receptor: Integrin alpha1beta1 · Integrin alpha2beta1 · Integrin alpha3beta1 · VLA-4 (CD49d+CD29)  · Alpha-5 beta-1 · Integrin alpha6beta1

Vitronectin receptor: Alpha-v beta-3 · Alpha-v beta-5
see also cell surface receptor deficiencies
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)