mir-103/107 microRNA precursor
The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation. miR-103 and miR-107 have now been predicted or experimentally confirmed in human.[1][2]
microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA.[3]
mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes.[4]
mir-103 has also been linked with chronic pain[5] and intestinal cell proliferation.[6]
References
- ^ Mourelatos Z, Dostie J, Paushkin S et al. (2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155365.
- ^ "miRNA gene family: mir-103". mirBASE. University of Manchester. http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000024. Retrieved 5 September 2011.
- ^ Ambros V (2001). "microRNAs: tiny regulators with great potential". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Trajkovski, M; Hausser, J, Soutschek, J, Bhat, B, Akin, A, Zavolan, M, Heim, MH, Stoffel, M (2011 Jun 8). "MicroRNAs 103 and 107 regulate insulin sensitivity". Nature 474 (7353): 649–53. doi:10.1038/nature10112. PMID 21654750.
- ^ Favereaux, A; Thoumine, O, Bouali-Benazzouz, R, Roques, V, Papon, MA, Salam, SA, Drutel, G, Léger, C, Calas, A, Nagy, F, Landry, M (2011 Jul 29). "Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain". The EMBO journal 30 (18): 3830–41. doi:10.1038/emboj.2011.249. PMID 21804529.
- ^ Liao, Y; Lönnerdal, B (2010 Sep 23). Langsley, Gordon. ed. "Global MicroRNA Characterization Reveals That miR-103 Is Involved in IGF-1 Stimulated Mouse Intestinal Cell Proliferation". PloS one 5 (9): e12976. doi:10.1371/journal.pone.0012976. PMC 2944884. PMID 20886090. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2944884.
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