| miR-33 | |
|---|---|
| Conserved secondary structure of miR-33 microRNA precursor | |
| Identifiers | |
| Symbol | miR-33 |
| Alt. Symbols | mir33 |
| Rfam | RF00667 |
| miRBase | MI0000091 |
| miRBase family | MIPF0000070 |
| Entrez | 407039 |
| HUGO | 31634 |
| Other data | |
| RNA type | miRNA |
| Domain(s) | Metazoa |
| GO | 0035195 |
| SO | 0001244 |
| Locus | Chr. 22 q13.2 |
miR-33 is a family of microRNA precursors, which are processed by the Dicer enzyme to give mature microRNAs.[1] miR-33 is found in several animal species, including humans, and gives the mature product mir-33. In humans, members of the miR-33 family are located in intronic regions within two protein-coding genes for Sterol regulatory element-binding proteins (SREBP-1 and SREBP-2).[2]
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miR-33 plays a role in lipid metabolism; it downregulates a number of ABC transporters, including ABCA1 and ABCG1, which in turn regulate cholesterol and HDL generation.[3][4] Further related roles of miR-33 have been proposed in fatty acid degradation and in macrophage response to low-density lipoprotein.[2]
Potential binding sites for mir-33 have been identified in the cDNA of tumour suppressor p53.[5] Further, study has shown that miR-33 is able to repress p53 expression and p53-induced apoptosis. This function is thought to be related to hematopoietic stem cell renewal.[6]
miR-33, along with miR-122, could be used to diagnose or treat conditions related to metabolic disorders and cardiovascular disease.[2][7]
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