miR-224 | |
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Conserved secondary structure of miR-224 microRNA precursor | |
Identifiers | |
Symbol | miR-224 |
Alt. Symbols | MIR224 |
Rfam | RF00680 |
miRBase | MI0000301 |
miRBase family | MIPF0000088 |
Entrez | 407009 |
HUGO | 31604 |
OMIM | 300769 |
RefSeq | NR_029638 |
Other data | |
RNA type | miRNA |
Domain(s) | Mammalia |
GO | 0035195 |
SO | 0001244 |
Locus | Chr. X q28 |
miR-224 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precusor hairpin by the enzyme Dicer.[1]
miR-224, being located on the X-chromosome, is thought to be active in mammalian ovaries, and possibly responds to TGF beta 1.[2] A target of miR-224 has been predicted to be SMAD4. Experimental evidence has shown that while the SMAD4 mRNA level is unchanged, increased miR-224 expression decreases concentration of SMDA4 protein in murine granulosa cells.[3] This is consistent with post-transcriptional miRNA regulation.[2]
miR-224 has been noted as the most upregulated microRNA in hepatocellular carcinoma.[4] The same study identified a target of mir-224 as apoptosis-inhibitor 5 (API-5).[4]
miR-224 has also been linked with pancreatic ductal carcinoma, where it is thought to repress CD40 expression in cancer cells.[5]
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