miR-144
miR-144 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precusor hairpin by the enzyme Dicer.[1] In humans, miR-144 has been characterised as a "common miRNA signature"[2] of a number of different tumours.
GATA4 is thought to activate transcription of the miR-144 microRNA precursor.[3]
Function
miR-144 functions in a cluster with miR-451. This locus regulates the expression of a number of genes whose products are involved in erythropoiesis.[4] One of the identified targets of miR-144 is insulin receptor substrate 1.[5]
Applications
miR-144 has been identified as one of a number of potential miRNA targets which could be used to treat schizophrenia and bipolar affective disorder.[6] It has also been suggested as a potential therapeutic tool to treat ischemic heart disease.[3]
References
- ^ Ambros, V (2001 Dec 28). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Wang, W; Peng, B, Wang, D, Ma, X, Jiang, D, Zhao, J, Yu, L (2011 Oct 1). "Human tumor microRNA signatures derived from large-scale oligonucleotide microarray datasets.". International journal of cancer. Journal international du cancer 129 (7): 1624–34. doi:10.1002/ijc.25818. PMID 21128228.
- ^ a b Zhang, X; Wang, X, Zhu, H, Zhu, C, Wang, Y, Pu, WT, Jegga, AG, Fan, GC (2010 Nov). "Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death.". Journal of molecular and cellular cardiology 49 (5): 841–50. doi:10.1016/j.yjmcc.2010.08.007. PMID 20708014.
- ^ Rasmussen, KD; Simmini, S, Abreu-Goodger, C, Bartonicek, N, Di Giacomo, M, Bilbao-Cortes, D, Horos, R, Von Lindern, M, Enright, AJ, O'Carroll, D (2010 Jul 5). "The miR-144/451 locus is required for erythroid homeostasis.". The Journal of experimental medicine 207 (7): 1351–8. doi:10.1084/jem.20100458. PMC 2901075. PMID 20513743. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2901075.
- ^ Karolina, DS; Armugam, A, Tavintharan, S, Wong, MT, Lim, SC, Sum, CF, Jeyaseelan, K (2011). "MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus.". PloS one 6 (8): e22839. doi:10.1371/journal.pone.0022839. PMC 3148231. PMID 21829658. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3148231.
- ^ Dinan, TG (2010 Apr). "MicroRNAs as a target for novel antipsychotics: a systematic review of an emerging field.". The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP) 13 (3): 395–404. doi:10.1017/S1461145709990800. PMID 19849891. (subscription required)
Further reading
- Zhang, HY; Zheng, SJ, Zhao, JH, Zhao, W, Zheng, LF, Zhao, D, Li, JM, Zhang, XF, Chen, ZB, Yi, XN (2011 Apr 6). "MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection.". Brain research 1383: 62–70. doi:10.1016/j.brainres.2011.01.067. PMID 21276775.
External links