ZRANB2

Zinc finger, RAN-binding domain containing 2

PDB rendering based on 1n0z.

Available structures
PDB	1N0Z, 2K1P, 3G9Y

Identifiers

ZRANB2; DKFZp686J1831; DKFZp686N09117; FLJ41119; ZIS; ZIS1; ZIS2; ZNF265

External IDs

OMIM: 604347 MGI: 1858211 HomoloGene: 3984 GeneCards: ZRANB2 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • RNA binding • protein binding • zinc ion binding • metal ion binding
Cellular component	• intracellular • nucleus
Biological process	• transcription, DNA-dependent • regulation of transcription, DNA-dependent • mRNA processing • RNA splicing
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000132485

ENSMUSG00000028180

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
71.53 – 71.55 Mb

Chr 3:
157.2 – 157.21 Mb

PubMed search

Zinc finger Ran-binding domain-containing protein 2 is a protein that in humans is encoded by the ZRANB2 gene.^[1]^[2]

Interactions

ZRANB2 has been shown to interact with U2 small nuclear RNA auxiliary factor 1^[3] and SNRP70.^[3]

References

^ Nakano M, Yoshiura K, Oikawa M, Miyoshi O, Yamada K, Kondo S, Miwa N, Soeda E, Jinno Y, Fujii T, Niikawa N (Feb 1999). "Identification, characterization and mapping of the human ZIS (zinc-finger, splicing) gene". Gene 225 (1–2): 59–65. doi:10.1016/S0378-1119(98)00536-8. PMID 9931435.
^ "Entrez Gene: ZRANB2 zinc finger, RAN-binding domain containing 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9406.
^ ^a ^b Adams, D J; van der Weyden L, Mayeda A, Stamm S, Morris B J, Rasko J E (Jul. 2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. (United States) 154 (1): 25–32. doi:10.1083/jcb.200010059. ISSN 0021-9525. PMC 2196870. PMID 11448987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196870.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Adams DJ, van der Weyden L, Kovacic A et al. (2000). "Chromosome localization and characterization of the mouse and human zinc finger protein 265 gene". Cytogenet. Cell Genet. 88 (1–2): 68–73. doi:10.1159/000015487. PMID 10773668.
Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
Suzuki Y, Tsunoda T, Sese J et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.164001. PMC 311086. PMID 11337467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311086.
Adams DJ, van der Weyden L, Mayeda A et al. (2001). "ZNF265--a novel spliceosomal protein able to induce alternative splicing". J. Cell Biol. 154 (1): 25–32. doi:10.1083/jcb.200010059. PMC 2196870. PMID 11448987. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2196870.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Plambeck CA, Kwan AH, Adams DJ et al. (2003). "The structure of the zinc finger domain from human splicing factor ZNF265 fold". J. Biol. Chem. 278 (25): 22805–22811. doi:10.1074/jbc.M301896200. PMID 12657633.
Li J, Hawkins IC, Harvey CD et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Mol. Cell. Biol. 23 (21): 7437–7447. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=207616.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Mangs AH, Speirs HJ, Goy C et al. (2006). "XE7: a novel splicing factor that interacts with ASF/SF2 and ZNF265". Nucleic Acids Res. 34 (17): 4976–4986. doi:10.1093/nar/gkl660. PMC 1635291. PMID 16982639. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1635291.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

1n0z: Solution structure of the first zinc-finger domain from ZNF265