ZHX1

Zinc fingers and homeoboxes 1

PDB rendering based on 2ecb.

Available structures
PDB	2ECB, 2GHF, 3NAR

Identifiers

Symbols

ZHX1;

External IDs

OMIM: 604764 MGI: 109271 HomoloGene: 5225 GeneCards: ZHX1 Gene

Gene Ontology
Molecular function	• sequence-specific DNA binding transcription factor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular component	• intracellular • nucleus
Biological process	• transcription, DNA-dependent • negative regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
124.26 – 124.29 Mb

Chr 15:
57.88 – 57.91 Mb

PubMed search

[1]

[2]

Zinc fingers and homeoboxes protein 1 is a protein that in humans is encoded by the ZHX1 gene.^[1]^[2]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 1 of this gene family. In addition to forming homodimers, this protein heterodimerizes with members 2 and 3 of the zinc fingers and homeoboxes family. Alternative splicing results in multiple transcript variants encoding the same protein.^[2]

Interactions

ZHX1 has been shown to interact with NFYA.^[1]^[3]

References

^ ^a ^b Yamada K, Printz RL, Osawa H, Granner DK (Sep 1999). "Human ZHX1: cloning, chromosomal location, and interaction with transcription factor NF-Y". Biochem Biophys Res Commun 261 (3): 614–21. doi:10.1006/bbrc.1999.1087. PMID 10441475.
^ ^a ^b "Entrez Gene: ZHX1 zinc fingers and homeoboxes 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11244.
^ Yamada, K; Osawa H, Granner D K (Oct. 1999). "Identification of proteins that interact with NF-YA". FEBS Lett. (NETHERLANDS) 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. ISSN 0014-5793. PMID 10571058.

Yamada K, Osawa H, Granner DK (1999). "Identification of proteins that interact with NF-YA.". FEBS Lett. 460 (1): 41–5. doi:10.1016/S0014-5793(99)01311-3. PMID 10571058.
Hirano S, Yamada K, Kawata H, et al. (2002). "Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer.". Gene 290 (1-2): 107–14. doi:10.1016/S0378-1119(02)00553-X. PMID 12062805.
Yamada K, Kawata H, Matsuura K, et al. (2002). "Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1).". Biochem. Biophys. Res. Commun. 297 (2): 368–74. doi:10.1016/S0006-291X(02)02203-9. PMID 12237128.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMC 1223464. PMID 12659632. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223464.
Kawata H, Yamada K, Shou Z, et al. (2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.". Biochem. J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMC 1223552. PMID 12741956. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223552.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
Kim SH, Park J, Choi MC, et al. (2007). "Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression.". Biochem. Biophys. Res. Commun. 355 (2): 318–23. doi:10.1016/j.bbrc.2007.01.187. PMID 17303076.

PDB gallery

2ecb: The solution structure of the third homeobox domain of human zinc fingers and homeoboxes protein

2ghf: Solution structure of the complete zinc-finger region of human zinc-fingers and homeoboxes 1 (ZHX1)

ZHX1

Interactions

References

Further reading