ZFX

Zinc finger protein, X-linked

PDB rendering based on 5znf.

Available structures
PDB	5znf

Identifiers

Symbols

ZFX;

External IDs

OMIM: 314980 MGI: 99211 HomoloGene: 2561 GeneCards: ZFX Gene

Gene Ontology
Molecular function	• DNA binding • transcription coactivator activity • zinc ion binding • metal ion binding
Cellular component	• intracellular • nucleus • nucleolus
Biological process	• regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
24.17 – 24.23 Mb

Chr X:
91.32 – 91.37 Mb

PubMed search

[1]

[2]

Zinc finger X-chromosomal protein is a protein that in humans is encoded by the ZFX gene.^[1]

References

^ "Entrez Gene: ZFX zinc finger protein, X-linked". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7543.

North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.". Nucleic Acids Res. 19 (10): 2579–86. doi:10.1093/nar/19.10.2579. PMC 328173. PMID 2041734. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=328173.
Mardon G, Luoh SW, Simpson EM, et al. (1990). "Mouse Zfx protein is similar to Zfy-2: each contains an acidic activating domain and 13 zinc fingers.". Mol. Cell. Biol. 10 (2): 681–8. PMC 360866. PMID 2105457. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=360866.
Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts.". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681–5. doi:10.1073/pnas.87.5.1681. PMC 53546. PMID 2308929. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53546.
Müller G, Schempp W (1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization.". Hum. Genet. 82 (1): 82–4. doi:10.1007/BF00288279. PMID 2497060.
Schneider-Gädicke A, Beer-Romero P, Brown LG, et al. (1989). "ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation.". Cell 57 (7): 1247–58. doi:10.1016/0092-8674(89)90061-5. PMID 2500252.
Schneider-Gädicke A, Beer-Romero P, Brown LG, et al. (1990). "Putative transcription activator with alternative isoforms encoded by human ZFX gene.". Nature 342 (6250): 708–11. doi:10.1038/342708a0. PMID 2512506.
Taylor DM, Ray PF, Ao A, et al. (1998). "Paternal transcripts for glucose-6-phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the three- to four-cell stage.". Mol. Reprod. Dev. 48 (4): 442–8. doi:10.1002/(SICI)1098-2795(199712)48:4<442::AID-MRD4>3.0.CO;2-Q. PMID 9364438.
Murphy WJ, Eizirik E, Johnson WE, et al. (2001). "Molecular phylogenetics and the origins of placental mammals.". Nature 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
Poloumienko A (2004). "Cloning and comparative analysis of the bovine, porcine, and equine sex chromosome genes ZFX and ZFY.". Genome 47 (1): 74–83. doi:10.1139/g03-099. PMID 15060604.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.

PDB gallery

5znf: ALTERNATING ZINC FINGERS IN THE HUMAN MALE ASSOCIATED PROTEIN ZFY: 2D NMR STRUCTURE OF AN EVEN FINGER AND IMPLICATIONS FOR ""JUMPING-LINKER"" DNA RECOGNITION

ZFX

References

Further reading