YAP1

Yes-associated protein 1

PDB rendering based on 1jmq.

Available structures
PDB	1JMQ, 1K5R, 1K9Q, 1K9R, 3KYS

Identifiers

Symbols

YAP1; YAP; YAP2; YAP65; YKI

External IDs

OMIM: 606608 MGI: 103262 HomoloGene: 4452 GeneCards: YAP1 Gene

Gene Ontology
Molecular function	• transcription coactivator activity • transcription corepressor activity • protein binding • transcription regulatory region DNA binding
Cellular component	• nucleus • cytoplasm
Biological process	• regulation of transcription, DNA-dependent • response to DNA damage stimulus • cell proliferation • hippo signaling cascade • contact inhibition • cellular response to gamma radiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
101.98 – 102.1 Mb

Chr 9:
7.93 – 8 Mb

PubMed search

[1]

[2]

65 kDa Yes-associated protein is a protein that in humans is encoded by the YAP1 gene.^[1]^[2]

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.^[2]

Interactions

YAP1 has been shown to interact with Mothers against decapentaplegic homolog 7,^[3] ERBB4,^[4] Sodium-hydrogen antiporter 3 regulator 1,^[5] TP53BP2^[6] and P73.^[7]

References

^ Sudol M, Bork P, Einbond A, Kastury K, Druck T, Negrini M, Huebner K, Lehman D (Jul 1995). "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain". J Biol Chem 270 (24): 14733–41. doi:10.1074/jbc.270.24.14733. PMID 7782338.
^ ^a ^b "Entrez Gene: YAP1 Yes-associated protein 1, 65kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10413.
^ Ferrigno, Olivier; Lallemand François, Verrecchia Franck, L'Hoste Sébastien, Camonis Jacques, Atfi Azeddine, Mauviel Alain (Jul. 2002). "Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling". Oncogene (England) 21 (32): 4879–84. doi:10.1038/sj.onc.1205623. ISSN 0950-9232. PMID 12118366.
^ Omerovic, Jasminka; Puggioni Eleonora M R, Napoletano Silvia, Visco Vincenzo, Fraioli Rocco, Frati Luigi, Gulino Alberto, Alimandi Maurizio (Apr. 2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Exp. Cell Res. (United States) 294 (2): 469–79. doi:10.1016/j.yexcr.2003.12.002. ISSN 0014-4827. PMID 15023535.
^ Mohler, P J; Kreda S M, Boucher R C, Sudol M, Stutts M J, Milgram S L (Nov. 1999). "Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50". J. Cell Biol. (UNITED STATES) 147 (4): 879–90. doi:10.1083/jcb.147.4.879. ISSN 0021-9525. PMC 2156157. PMID 10562288. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2156157.
^ Espanel, X; Sudol M (Apr. 2001). "Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains". J. Biol. Chem. (United States) 276 (17): 14514–23. doi:10.1074/jbc.M008568200. ISSN 0021-9258. PMID 11278422.
^ Strano, S; Munarriz E, Rossi M, Castagnoli L, Shaul Y, Sacchi A, Oren M, Sudol M, Cesareni G, Blandino G (May. 2001). "Physical interaction with Yes-associated protein enhances p73 transcriptional activity". J. Biol. Chem. (United States) 276 (18): 15164–73. doi:10.1074/jbc.M010484200. ISSN 0021-9258. PMID 11278685.

Sudol M, Chen HI, Bougeret C et al. (1995). "Characterization of a novel protein-binding module--the WW domain". FEBS Lett. 369 (1): 67–71. doi:10.1016/0014-5793(95)00550-S. PMID 7641887.
Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. doi:10.1073/pnas.92.17.7819. PMC 41237. PMID 7644498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41237.
Chen HI, Einbond A, Kwak SJ et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands". J. Biol. Chem. 272 (27): 17070–7. doi:10.1074/jbc.272.27.17070. PMID 9202023.
Gavva NR, Gavva R, Ermekova K et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II". J. Biol. Chem. 272 (39): 24105–8. doi:10.1074/jbc.272.39.24105. PMID 9305852.
Yagi R, Chen LF, Shigesada K et al. (1999). "A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator". EMBO J. 18 (9): 2551–62. doi:10.1093/emboj/18.9.2551. PMC 1171336. PMID 10228168. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171336.
Mohler PJ, Kreda SM, Boucher RC et al. (1999). "Yes-Associated Protein 65 Localizes P62c-Yes to the Apical Compartment of Airway Epithelia by Association with Ebp50". J. Cell Biol. 147 (4): 879–90. doi:10.1083/jcb.147.4.879. PMC 2156157. PMID 10562288. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2156157.
Espanel X, Sudol M (2001). "Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains". J. Biol. Chem. 276 (17): 14514–23. doi:10.1074/jbc.M008568200. PMID 11278422.
Strano S, Munarriz E, Rossi M et al. (2001). "Physical interaction with Yes-associated protein enhances p73 transcriptional activity". J. Biol. Chem. 276 (18): 15164–73. doi:10.1074/jbc.M010484200. PMID 11278685.
Vassilev A, Kaneko KJ, Shu H et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=313800.
Pires JR, Taha-Nejad F, Toepert F et al. (2002). "Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope". J. Mol. Biol. 314 (5): 1147–56. doi:10.1006/jmbi.2000.5199. PMID 11743730.
Ferrigno O, Lallemand F, Verrecchia F et al. (2002). "Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling". Oncogene 21 (32): 4879–84. doi:10.1038/sj.onc.1205623. PMID 12118366.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Basu S, Totty NF, Irwin MS et al. (2003). "Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis". Mol. Cell 11 (1): 11–23. doi:10.1016/S1097-2765(02)00776-1. PMID 12535517.
Komuro A, Nagai M, Navin NE, Sudol M (2003). "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus". J. Biol. Chem. 278 (35): 33334–41. doi:10.1074/jbc.M305597200. PMID 12807903.
Omerovic J, Puggioni EM, Napoletano S et al. (2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level". Exp. Cell Res. 294 (2): 469–79. doi:10.1016/j.yexcr.2003.12.002. PMID 15023535.
Howell M, Borchers C, Milgram SL (2004). "Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription". J. Biol. Chem. 279 (25): 26300–6. doi:10.1074/jbc.M401070200. PMID 15096513.
Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Levy D, Adamovich Y, Reuven N, Shaul Y. (2007). "The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73". Cell Death and Differentiation. 14 (4): 743–51. doi:10.1038/sj.cdd.4402063. PMID 17110958.
Levy D, Adamovich Y, Reuven N, Shaul Y. (2008). "Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage". Molecular Cell. 29 (3): 350–61. doi:10.1016/j.molcel.2007.12.022. PMID 18280240.

PDB gallery

1jmq: YAP65 (L30K mutant) WW domain in Complex with GTPPPPYTVG peptide

1k5r: YAP65 WW domain S24-Amino-Ethylsulfanyl-Acetic Acid mutant

1k9q: YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2

1k9r: YAP65 WW domain complexed to Acetyl-PLPPY

Signaling pathway: Hippo signaling pathway

Receptor	FAT4

Adaptor protein	NF2 · FRMD6 · SAV1 · MOBKL1A, MOBKL1B

Kinase	MST1, MST2 · LATS1, LATS2

Transcription factor	YAP1, TAZ

Other/unknown	RASSF1

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

YAP1

Interactions

References

Further reading