Y-27632

Y-27632

IUPAC name (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide
Identifiers
CAS number	146986-50-7^Y
PubChem	448042
ChemSpider	20016532^Y
DrugBank	DB08756
Jmol-3D images	Image 1
SMILES O=C([C@H]1CC[C@@]([C@H](N)C)([H])CC1)NC2=CC=NC=C2
InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1^Y Key: IYOZTVGMEWJPKR-IJLUTSLNSA-N^Y InChI=1/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 Key: IYOZTVGMEWJPKR-IJLUTSLNBP
Properties
Molecular formula	C₁₄H₂₁N₃O
Molar mass	247.34 g mol⁻¹
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Y-27632 is a biochemical tool used in the study of the rho-associated protein kinase (ROCK) signaling pathways.^[1] Y-27632 selectively inhibits p160ROCK.^[2]

References

^ Uehata, Masayoshi (1999). "Y-27632. Selective probe of ROCK/Rho-kinase". Jikken Igaku 17 (7): 850–855.
^ Uehata, M; Ishizaki, T; Satoh, H; Ono, T; Kawahara, T; Morishita, T; Tamakawa, H; Yamagami, K et al. (1997). "Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension". Nature 389 (6654): 990–4. doi:10.1038/40187. PMID 9353125.