WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1 is an enzyme that in humans is encoded by the WWP1 gene.[1][2][3]
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.[3]
Interactions
WWP1 has been shown to interact with KLF2,[4] Reticulon 4[5] and CPSF6.[6]
References
- ^ Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (Jun 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J Biol Chem 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
- ^ Wood JD, Yuan J, Margolis RL, Colomer V, Duan K, Kushi J, Kaminsky Z, Kleiderlein JJ, Sharp AH, Ross CA (Jul 1998). "Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins". Mol Cell Neurosci 11 (3): 149–60. doi:10.1006/mcne.1998.0677. PMID 9647693.
- ^ a b "Entrez Gene: WWP1 WW domain containing E3 ubiquitin protein ligase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11059.
- ^ Conkright, M D; Wani M A, Lingrel J B (Aug. 2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase". J. Biol. Chem. (United States) 276 (31): 29299–306. doi:10.1074/jbc.M103670200. ISSN 0021-9258. PMID 11375995.
- ^ Qin, Haina; Pu Helen X, Li Minfen, Ahmed Sohail, Song Jianxing (Dec. 2008). "Identification and structural mechanism for a novel interaction between a ubiquitin ligase WWP1 and Nogo-A, a key inhibitor for central nervous system regeneration". Biochemistry (United States) 47 (51): 13647–58. doi:10.1021/bi8017976. PMID 19035836.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Mosser EA, Kasanov JD, Forsberg EC, et al. (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains.". Biochemistry 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
- Conkright MD, Wani MA, Lingrel JB (2001). "Lung Krüppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase.". J. Biol. Chem. 276 (31): 29299–306. doi:10.1074/jbc.M103670200. PMID 11375995.
- Flasza M, Gorman P, Roylance R, et al. (2002). "Alternative splicing determines the domain structure of WWP1, a Nedd4 family protein.". Biochem. Biophys. Res. Commun. 290 (1): 431–7. doi:10.1006/bbrc.2001.6206. PMID 11779188.
- Galinier R, Gout E, Lortat-Jacob H, et al. (2003). "Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.". Biochemistry 41 (48): 14299–305. doi:10.1021/bi020125b. PMID 12450395.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Verdecia MA, Joazeiro CA, Wells NJ, et al. (2003). "Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase.". Mol. Cell 11 (1): 249–59. doi:10.1016/S1097-2765(02)00774-8. PMID 12535537.
- Komuro A, Imamura T, Saitoh M, et al. (2004). "Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1).". Oncogene 23 (41): 6914–23. doi:10.1038/sj.onc.1207885. PMID 15221015.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Seo SR, Lallemand F, Ferrand N, et al. (2005). "The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation.". EMBO J. 23 (19): 3780–92. doi:10.1038/sj.emboj.7600398. PMC 522797. PMID 15359284. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522797.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chen C, Sun X, Guo P, et al. (2006). "Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells.". J. Biol. Chem. 280 (50): 41553–61. doi:10.1074/jbc.M506183200. PMID 16223724.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- Flasza M, Nguyen Huu NS, Mazaleyrat S, et al. (2006). "Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch.". Mol. Membr. Biol. 23 (3): 269–76. doi:10.1080/09687860600665010. PMID 16785210.
- Laine A, Ronai Z (2007). "Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1.". Oncogene 26 (10): 1477–83. doi:10.1038/sj.onc.1209924. PMC 2997392. PMID 16924229. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2997392.
- Chen C, Sun X, Guo P, et al. (2007). "Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer.". Oncogene 26 (16): 2386–94. doi:10.1038/sj.onc.1210021. PMID 17016436.
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1nd7: Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT domain E3 Ligase
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