wingless-type MMTV integration site family, member 6 | |
---|---|
Identifiers | |
Symbol | WNT6 |
Entrez | 7475 |
HUGO | 12785 |
OMIM | 604663 |
RefSeq | NM_006522 |
UniProt | Q9Y6F9 |
Other data | |
Locus | Chr. 2 q35 |
Wingless-type MMTV integration site family, member 6, also known as WNT6, is a human gene.[1][2]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, which are involved in the Wnt signaling pathway. It is overexpressed in cervical cancer cell line and strongly coexpressed with another family member, WNT10A, in colorectal cancer cell line.[3] The gene overexpression may play key roles in carcinogenesis. This gene and the WNT10A gene are clustered in the chromosome 2q35 region. The protein encoded by this gene is 97% identical to the mouse Wnt6 protein at the amino acid level.[1]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.