WNT4

Wingless-type MMTV integration site family, member 4
Identifiers
Symbols WNT4; SERKAL; WNT-4
External IDs OMIM: 603490 MGI: 98957 HomoloGene: 22529 GeneCards: WNT4 Gene
Orthologs
Species Human Mouse
Entrez 54361 22417
Ensembl ENSG00000162552 ENSMUSG00000036856
UniProt P56705 P22724
RefSeq (mRNA) NM_030761 NM_009523.1
RefSeq (protein) NP_110388 NP_033549.1
Location (UCSC) Chr 1:
22.45 – 22.47 Mb		 Chr 4:
136.83 – 136.86 Mb
PubMed search [1] [2]

Protein Wnt-4 is a protein that in humans is encoded by the WNT4 gene.[1][2]

WNT4 is a secreted protein involved in female fetal genital development.[3]

Contents

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein showing 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation.[1]

Clinical significance

This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome.[1]

References

  1. ^ a b c "Entrez Gene: wingless-type MMTV integration site family". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54361. 
  2. ^ Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (May 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res. 54 (10): 2615–21. PMID 8168088. 
  3. ^ Bernard P, Harley VR (2007). "Wnt4 action in gonadal development and sex determination". Int. J. Biochem. Cell Biol. 39 (1): 31–43. doi:10.1016/j.biocel.2006.06.007. PMID 16905353. 

Further reading

External Links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Intercellular signaling peptides and proteins / ligands
Growth factors
Ephrin
EFNA1 • EFNA2 • EFNA3 • EFNA4 • EFNA5 • EFNB1 • EFNB2 • EFNB3
Other
see also extracellular ligand disorders
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)