WNT2

Wingless-type MMTV integration site family member 2

Identifiers

WNT2; INT1L1; IRP

External IDs

OMIM: 147870 MGI: 98954 HomoloGene: 20719 GeneCards: WNT2 Gene

Gene Ontology
Molecular function	• signal transducer activity • frizzled binding • frizzled-2 binding • cytokine activity
Cellular component	• extracellular region • proteinaceous extracellular matrix • extracellular space • cytoplasm • plasma membrane • extracellular matrix
Biological process	• positive regulation of endothelial cell proliferation • positive regulation of mesenchymal cell proliferation • lens development in camera-type eye • Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • multicellular organismal development • positive regulation of cell proliferation • dorsal/ventral axis specification • Wnt receptor signaling pathway • neuron differentiation • lung development • positive regulation of transcription from RNA polymerase II promoter • positive regulation of fibroblast proliferation • positive regulation of sequence-specific DNA binding transcription factor activity • atrial cardiac muscle tissue morphogenesis • positive regulation of cardiac muscle cell proliferation • canonical Wnt receptor signaling pathway • cardiac epithelial to mesenchymal transition • lung induction • positive regulation of epithelial cell proliferation involved in lung morphogenesis • labyrinthine layer blood vessel development • iris morphogenesis • mammary gland epithelium development • cellular response to retinoic acid • cellular response to transforming growth factor beta stimulus • positive regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
116.92 – 116.96 Mb

Chr 6:
17.94 – 17.98 Mb

PubMed search

[1]

[2]

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.^[1]^[2]

This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.^[1]

References

^ ^a ^b "Entrez Gene: WNT2 wingless-type MMTV integration site family, member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7472.
^ Wainwright BJ, Scambler PJ, Stanier P, Watson EK, Bell G, Wicking C, Estivill X, Courtney M, Boue A, Pedersen PS (June 1988). "Isolation of a human gene with protein sequence similarity to human and murine int-1 and the Drosophila segment polarity mutant wingless". EMBO J. 7 (6): 1743–8. PMC 457162. PMID 2971536. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=457162.

Katoh M (2003). "WNT2 and human gastrointestinal cancer (review).". Int. J. Mol. Med. 12 (5): 811–6. PMID 14533014.
Li J, Nguyen L, Gleason C, et al. (2004). "Lack of evidence for an association between WNT2 and RELN polymorphisms and autism.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 126B (1): 51–7. doi:10.1002/ajmg.b.20122. PMID 15048648.
Pu P, Zhang Z, Kang C, et al. (2009). "Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth.". Cancer Gene Ther. 16 (4): 351–61. doi:10.1038/cgt.2008.78. PMID 18949017.
Kodo K, Nishizawa T, Furutani M, et al. (2009). "GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 13933–8. doi:10.1073/pnas.0904744106. PMC 2728998. PMID 19666519. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2728998.
ClÃ©ment G, Braunschweig R, Pasquier N, et al. (2006). "Alterations of the Wnt signaling pathway during the neoplastic progression of Barrett's esophagus.". Oncogene 25 (21): 3084–92. doi:10.1038/sj.onc.1209338. PMID 16407829.
Park JK, Song JH, He TC, et al. (2009). "Overexpression of Wnt-2 in colorectal cancers.". Neoplasma 56 (2): 119–23. doi:10.4149/neo_2009_02_119. PMID 19239325.
Flahaut M, Meier R, Coulon A, et al. (2009). "The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway.". Oncogene 28 (23): 2245–56. doi:10.1038/onc.2009.80. PMID 19421142.
Liu ZL, Li Y, Kong QY, et al. (2008). "Immunohistochemical profiling of Wnt, NF-kappaB, Stat3 and Notch signaling in human epidermal tumors.". J. Dermatol. Sci. 52 (2): 133–6. doi:10.1016/j.jdermsci.2008.06.011. PMID 18703315.
Kloth JN, Fleuren GJ, Oosting J, et al. (2005). "Substantial changes in gene expression of Wnt, MAPK and TNFalpha pathways induced by TGF-beta1 in cervical cancer cell lines.". Carcinogenesis 26 (9): 1493–502. doi:10.1093/carcin/bgi110. PMID 15878915.
Mazieres J, You L, He B, et al. (2005). "Wnt2 as a new therapeutic target in malignant pleural mesothelioma.". Int. J. Cancer 117 (2): 326–32. doi:10.1002/ijc.21160. PMID 15900580.
Wang HX, Tekpetey FR, Kidder GM (2009). "Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.". Mol. Hum. Reprod. 15 (1): 11–7. doi:10.1093/molehr/gan070. PMID 19038973.
Han JC, Zhang KL, Chen XY, et al. (2007). "Expression of seven gastric cancer-associated genes and its relevance for Wnt, NF-kappaB and Stat3 signaling.". APMIS 115 (12): 1331–43. doi:10.1111/j.1600-0643.2007.00695.x. PMID 18184402.
Planutis K, Planutiene M, Moyer MP, et al. (2007). "Regulation of norrin receptor frizzled-4 by Wnt2 in colon-derived cells.". BMC Cell Biol. 8: 12. doi:10.1186/1471-2121-8-12. PMC 1847812. PMID 17386109. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847812.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cheng XX, Wang ZC, Chen XY, et al. (2005). "Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin.". Clin. Exp. Metastasis 22 (1): 85–93. doi:10.1007/s10585-005-4578-8. PMID 16132582.
Shi Y, He B, Kuchenbecker KM, et al. (2007). "Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells.". Int. J. Cancer 121 (6): 1175–81. doi:10.1002/ijc.22848. PMID 17534895.
Cheng XX, Wang ZC, Chen XY, et al. (2005). "Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: relevance with tumour dissemination.". Cancer Lett. 223 (2): 339–47. doi:10.1016/j.canlet.2004.11.013. PMID 15896469.
Ma XR, Edmund Sim UH, Pauline B, et al. (2008). "Overexpression of WNT2 and TSG101 genes in colorectal carcinoma.". Tropical biomedicine 25 (1): 46–57. PMID 18600204.
de Krom M, Staal WG, Ophoff RA, et al. (2009). "A common variant in DRD3 receptor is associated with autism spectrum disorder.". Biol. Psychiatry 65 (7): 625–30. doi:10.1016/j.biopsych.2008.09.035. PMID 19058789.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

WNT2

References

Further reading