WNT10B
Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene.[1][2][3][4]
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is, it is presumed, a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region.[4]
References
- ^ Bui TD, Rankin J, Smith K, Huguet EL, Ruben S, Strachan T, Harris AL, Lindsay S (Apr 1997). "A novel human Wnt gene, WNT10B, maps to 12q13 and is expressed in human breast carcinomas". Oncogene 14 (10): 1249–53. doi:10.1038/sj.onc.1200936. PMID 9121776.
- ^ Hardiman G, Kastelein RA, Bazan JF (Sep 1997). "Isolation, characterization and chromosomal localization of human WNT10B". Cytogenet Cell Genet 77 (3–4): 278–82. doi:10.1159/000134597. PMID 9284937.
- ^ Ugur SA, Tolun A (Aug 2008). "Homozygous WNT10b mutation and complex inheritance in Split-Hand/Foot Malformation". Hum Mol Genet 17 (17): 2644–53. doi:10.1093/hmg/ddn164. PMID 18515319.
- ^ a b "Entrez Gene: WNT10B wingless-type MMTV integration site family, member 10B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7480.
Further reading
- Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". Mol. Biol. Cell 4 (12): 1267–75. doi:10.1051/jp3:1994201. PMC 275763. PMID 8167409. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=275763.
- Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21". Genomics 46 (3): 450–8. doi:10.1006/geno.1997.5041. PMID 9441749.
- Ross SE, Hemati N, Longo KA, et al. (2000). "Inhibition of adipogenesis by Wnt signaling". Science 289 (5481): 950–3. doi:10.1126/science.289.5481.950. PMID 10937998.
- Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055.
- Saitoh T, Kirikoshi H, Mine T, Katoh M (2002). "Proto-oncogene WNT10B is up-regulated by tumor necrosis factor alpha in human gastric cancer cell line MKN45". Int. J. Oncol. 19 (6): 1187–92. PMID 11713588.
- Kasat K, Go V, Pogo BG (2003). "Effects of pyrethroid insecticides and estrogen on WNT10B proto-oncogene expression". Environment international 28 (5): 429–32. doi:10.1016/S0160-4120(02)00072-7. PMID 12437293.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Christodoulides C, Scarda A, Granzotto M, et al. (2006). "WNT10B mutations in human obesity". Diabetologia 49 (4): 678–84. doi:10.1007/s00125-006-0144-4. PMID 16477437.