WNT1

Wingless-type MMTV integration site family, member 1
Identifiers
Symbols WNT1; INT1
External IDs OMIM: 164820 MGI: 98953 HomoloGene: 3963 GeneCards: WNT1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7471 22408
Ensembl ENSG00000125084 ENSMUSG00000022997
UniProt P04628 Q3UR96
RefSeq (mRNA) NM_005430.3 NM_021279.4
RefSeq (protein) NP_005421.1 NP_067254.1
Location (UCSC) Chr 12:
49.37 – 49.38 Mb		 Chr 15:
98.62 – 98.62 Mb
PubMed search [1] [2]

Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene.[1][2]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.[3]

References

  1. ^ van Ooyen A, Kwee V, Nusse R (Jan 1986). "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences". EMBO J 4 (11): 2905–9. PMC 554596. PMID 2998762. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=554596. 
  2. ^ Arheden K, Mandahl N, Strombeck B, Isaksson M, Mitelman F (May 1988). "Chromosome localization of the human oncogene INT1 to 12q13 by in situ hybridization". Cytogenet Cell Genet 47 (1–2): 86–87. doi:10.1159/000132513. PMID 3281802. 
  3. ^ "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7471. 

Further reading

  • McMahon AP, Moon RT (1990). "int-1--a proto-oncogene involved in cell signalling". Development 107 Suppl: 161–7. PMID 2534596. 
  • Chance PF, Cavalier L, Satran D et al. (1999). "Clinical nosologic and genetic aspects of Joubert and related syndromes". J. Child Neurol. 14 (10): 660–666. doi:10.1177/088307389901401007. PMID 10511339. 
  • De Ferrari GV, Moon RT (2007). "The ups and downs of Wnt signaling in prevalent neurological disorders". Oncogene 25 (57): 7545–7553. doi:10.1038/sj.onc.1210064. PMID 17143299. 
  • Thomas KR, Capecchi MR (1990). "Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development". Nature 346 (6287): 847–850. doi:10.1038/346847a0. PMID 2202907. 
  • Turc-Carel C, Pietrzak E, Kakati S et al. (1988). "The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11)". Oncogene Res. 1 (4): 397–405. PMID 3329717. 
  • Wang YK, Samos CH, Peoples R et al. (1997). "A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23". Hum. Mol. Genet. 6 (3): 465–472. doi:10.1093/hmg/6.3.465. PMID 9147651. 
  • Bafico A, Gazit A, Pramila T et al. (1999). "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling". J. Biol. Chem. 274 (23): 16180–16187. doi:10.1074/jbc.274.23.16180. PMID 10347172. 
  • Gazit A, Yaniv A, Bafico A et al. (1999). "Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response". Oncogene 18 (44): 5959–5966. doi:10.1038/sj.onc.1202985. PMID 10557084. 
  • Lee CS, Buttitta LA, May NR et al. (2000). "SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm". Development 127 (1): 109–18. PMID 10654605. 
  • Tanaka K, Okabayashi K, Asashima M et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family". Eur. J. Biochem. 267 (13): 4300–4311. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835. 
  • Tamai K, Semenov M, Kato Y et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction". Nature 407 (6803): 530–535. doi:10.1038/35035117. PMID 11029007. 
  • Mao J, Wang J, Liu B et al. (2001). "Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway". Mol. Cell 7 (4): 801–809. doi:10.1016/S1097-2765(01)00224-6. PMID 11336703. 
  • Kirikoshi H, Sekihara H, Katoh M (2001). "WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells". Biochem. Biophys. Res. Commun. 283 (4): 798–805. doi:10.1006/bbrc.2001.4855. PMID 11350055. 
  • Semënov MV, Tamai K, Brott BK et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. 
  • Mizushima T, Nakagawa H, Kamberov YG et al. (2002). "Wnt-1 but not epidermal growth factor induces beta-catenin/T-cell factor-dependent transcription in esophageal cancer cells". Cancer Res. 62 (1): 277–82. PMID 11782388. 
  • Tice DA, Szeto W, Soloviev I et al. (2002). "Synergistic induction of tumor antigens by Wnt-1 signaling and retinoic acid revealed by gene expression profiling". J. Biol. Chem. 277 (16): 14329–14335. doi:10.1074/jbc.M200334200. PMID 11832495.