WNK3

WNK lysine deficient protein kinase 3

Identifiers

WNK3; FLJ30437; FLJ42662; KIAA1566; PRKWNK3

External IDs

OMIM: 300358 MGI: 2652875 HomoloGene: 32493 GeneCards: WNK3 Gene

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • protein kinase activity • protein serine/threonine kinase activity • protein binding • ATP binding • sodium ion transmembrane transporter activity • rubidium ion transmembrane transporter activity
Cellular component	• adherens junction • tight junction
Biological process	• protein phosphorylation • intracellular protein kinase cascade • positive regulation of sodium ion transport • positive regulation of peptidyl-threonine phosphorylation • positive regulation of ion transmembrane transporter activity • rubidium ion transport • protein autophosphorylation • sodium ion export • positive regulation of establishment of protein localization in plasma membrane • positive regulation of sodium ion transmembrane transporter activity • positive regulation of rubidium ion transport • positive regulation of rubidium ion transmembrane transporter activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
54.22 – 54.39 Mb

Chr X:
147.63 – 147.75 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.^[1]

Function

WNK3 is a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca²⁺ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.^[1]

References

^ ^a ^b "Entrez Gene: WNK lysine deficient protein kinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65267.

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
Nagase T, Kikuno R, Nakayama M, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Yang CL, Zhu X, Ellison DH (2007). "The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.". J. Clin. Invest. 117 (11): 3403–11. doi:10.1172/JCI32033. PMID 17975670.
Rinehart J, Kahle KT, de Los Heros P, et al. (2005). "WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.". Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16777–82. doi:10.1073/pnas.0508303102. PMC 1283841. PMID 16275913. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1283841.
Ko B, Hoover RS (2009). "Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter.". Curr. Opin. Nephrol. Hypertens. 18 (5): 421–7. doi:10.1097/MNH.0b013e32832f2fcb. PMID 19636250.
San-Cristobal P, Ponce-Coria J, VÃ¡zquez N, et al. (2008). "WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.". Am. J. Physiol. Renal Physiol. 295 (4): F1199-206. doi:10.1152/ajprenal.90396.2008. PMID 18701621.
Glover M, Zuber AM, O'Shaughnessy KM (2009). "Renal and brain isoforms of WNK3 have opposite effects on NCCT expression.". J. Am. Soc. Nephrol. 20 (6): 1314–22. doi:10.1681/ASN.2008050542. PMID 19470686.
Auffray C, Behar G, Bois F, et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression].". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
Kahle KT, Ring AM, Lifton RP (2008). "Molecular physiology of the WNK kinases.". Annu. Rev. Physiol. 70: 329–55. doi:10.1146/annurev.physiol.70.113006.100651. PMID 17961084.
Zhang W, Na T, Peng JB (2008). "WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.". Am. J. Physiol. Renal Physiol. 295 (5): F1472-84. doi:10.1152/ajprenal.90229.2008. PMID 18768590.
VerÃssimo F, Silva E, Morris JD, et al. (2006). "Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway.". Oncogene 25 (30): 4172–82. doi:10.1038/sj.onc.1209449. PMID 16501604.
Moniz S, Jordan P (2010). "Emerging roles for WNK kinases in cancer.". Cell. Mol. Life Sci. 67 (8): 1265–76. doi:10.1007/s00018-010-0261-6. PMID 20094755.
Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2775832.
Qiao Y, Liu X, Harvard C, et al. (2008). "Autism-associated familial microdeletion of Xp11.22.". Clin. Genet. 74 (2): 134–44. doi:10.1111/j.1399-0004.2008.01028.x. PMID 18498374.
Wilson FH, Disse-NicodÃ¨me S, Choate KA, et al. (2001). "Human hypertension caused by mutations in WNK kinases.". Science 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.
Heise CJ, Xu BE, Deaton SL, et al. (2010). "Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.". J. Biol. Chem. 285 (33): 25161–7. doi:10.1074/jbc.M110.103432. PMID 20525693.
Holden S, Cox J, Raymond FL (2004). "Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3).". Gene 335: 109–19. doi:10.1016/j.gene.2004.03.009. PMID 15194194.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
VerÃssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.". Oncogene 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.". Diabetes Care 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2945168.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

WNK3

Function

References

Further reading