WNK2

WNK lysine deficient protein kinase 2

Identifiers

WNK2; KIAA1760; NY-CO-43; P/OKcl.13; PRKWNK2; SDCCAG43

External IDs

OMIM: 606249 MGI: 1922857 HomoloGene: 19155 GeneCards: WNK2 Gene

2.7.11.1

Gene Ontology
Molecular function	• nucleotide binding • protein serine/threonine kinase activity • protein binding • ATP binding
Biological process	• protein phosphorylation • intracellular protein kinase cascade
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
95.95 – 96.08 Mb

Chr 13:
49.13 – 49.24 Mb

PubMed search

[1]

[2]

Serine/threonine-protein kinase WNK2 is an enzyme that in humans is encoded by the WNK2 gene.^[1]^[2]^[3]

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine.^[3]

References

^ Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Tureci O, Sahin U, Pfreundschuh M, Old LJ (Jun 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int J Cancer 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
^ Verissimo F, Jordan P (Sep 2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
^ ^a ^b "Entrez Gene: WNK2 WNK lysine deficient protein kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=65268.

Nagase T, Kikuno R, Hattori A et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Ito M, Shichijo S, Tsuda N et al. (2001). "Molecular basis of T cell-mediated recognition of pancreatic cancer cells". Cancer Res. 61 (5): 2038–46. PMID 11280764.
Wilson FH, Disse-Nicodème S, Choate KA et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Moniz S, Veríssimo F, Matos P et al. (2007). "Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2". Oncogene 26 (41): 6071–81. doi:10.1038/sj.onc.1210706. PMID 17667937.

WNK2

References

Further reading