WNT1-inducible-signaling pathway protein 2

WNT1 inducible signaling pathway protein 2

Identifiers

WISP2; CCN5; CT58; CTGF-L

External IDs

OMIM: 603399 MGI: 1328326 HomoloGene: 2882 GeneCards: WISP2 Gene

Gene Ontology
Molecular function	• insulin-like growth factor binding
Cellular component	• extracellular region • soluble fraction • cytoplasm • plasma membrane • cell surface
Biological process	• regulation of cell growth • cell adhesion • signal transduction • cell-cell signaling • negative regulation of cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
43.34 – 43.36 Mb

Chr 2:
163.65 – 163.66 Mb

PubMed search

[1]

[2]

WNT1-inducible-signaling pathway protein 2 is a protein that in humans is encoded by the WISP2 gene.^[1]^[2]

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.^[2]

References

^ Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, Watanabe C, Cohen RL, Melhem MF, Finley GG, Quirke P, Goddard AD, Hillan KJ, Gurney AL, Botstein D, Levine AJ (Jan 1999). "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors". Proc Natl Acad Sci U S A 95 (25): 14717–22. doi:10.1073/pnas.95.25.14717. PMC 24515. PMID 9843955. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24515.
^ ^a ^b "Entrez Gene: WISP2 WNT1 inducible signaling pathway protein 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8839.

Kumar S, Hand AT, Connor JR, et al. (1999). "Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions.". J. Biol. Chem. 274 (24): 17123–31. doi:10.1074/jbc.274.24.17123. PMID 10358067.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Saxena N, Banerjee S, Sengupta K, et al. (2002). "Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines.". Mol. Cell. Biochem. 228 (1-2): 99–104. doi:10.1023/A:1013338912642. PMID 11855747.
Inadera H, Dong HY, Matsushima K (2002). "WISP-2 is a secreted protein and can be a marker of estrogen exposure in MCF-7 cells.". Biochem. Biophys. Res. Commun. 294 (3): 602–8. doi:10.1016/S0006-291X(02)00530-2. PMID 12056810.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Banerjee S, Saxena N, Sengupta K, et al. (2003). "WISP-2 gene in human breast cancer: estrogen and progesterone inducible expression and regulation of tumor cell proliferation.". Neoplasia 5 (1): 63–73. PMC 1502127. PMID 12659671. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1502127.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Bourdeau I, Antonini SR, Lacroix A, et al. (2004). "Gene array analysis of macronodular adrenal hyperplasia confirms clinical heterogeneity and identifies several candidate genes as molecular mediators.". Oncogene 23 (8): 1575–85. doi:10.1038/sj.onc.1207277. PMID 14767469.
Mason HR, Lake AC, Wubben JE, et al. (2004). "The growth arrest-specific gene CCN5 is deficient in human leiomyomas and inhibits the proliferation and motility of cultured human uterine smooth muscle cells.". Mol. Hum. Reprod. 10 (3): 181–7. doi:10.1093/molehr/gah028. PMID 14981145.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Banerjee S, Sengupta K, Saxena NK, et al. (2005). "Epidermal growth factor induces WISP-2/CCN5 expression in estrogen receptor-alpha-positive breast tumor cells through multiple molecular cross-talks.". Mol. Cancer Res. 3 (3): 151–62. doi:10.1158/1541-7786.MCR-04-0130. PMID 15798095.
Tanaka I, Morikawa M, Okuse T, et al. (2005). "Expression and regulation of WISP2 in rheumatoid arthritic synovium.". Biochem. Biophys. Res. Commun. 334 (4): 973–8. doi:10.1016/j.bbrc.2005.06.196. PMID 16038875.
Kouzu Y, Uzawa K, Kato M, et al. (2006). "WISP-2 expression in human salivary gland tumors.". Int. J. Mol. Med. 17 (4): 567–73. PMID 16525711.
Sengupta K, Banerjee S, Dhar K, et al. (2006). "WISP-2/CCN5 is involved as a novel signaling intermediate in phorbol ester-protein kinase Calpha-mediated breast tumor cell proliferation.". Biochemistry 45 (35): 10698–709. doi:10.1021/bi060888p. PMID 16939222.
Dhar G, Mehta S, Banerjee S, et al. (2007). "Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition.". Cancer Lett. 254 (1): 63–70. doi:10.1016/j.canlet.2007.02.012. PMID 17383817.
Davies SR, Watkins G, Mansel RE, Jiang WG (2007). "Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer.". Ann. Surg. Oncol. 14 (6): 1909–18. doi:10.1245/s10434-007-9376-x. PMID 17406949.

WNT1-inducible-signaling pathway protein 2

References

Further reading