WNT1-inducible-signaling pathway protein 1

WNT1 inducible signaling pathway protein 1

Identifiers

WISP1; CCN4; FLJ14388; WISP1c; WISP1i; WISP1tc

External IDs

OMIM: 603398 MGI: 1197008 HomoloGene: 2883 GeneCards: WISP1 Gene

Gene Ontology
Molecular function	• protein binding • insulin-like growth factor binding
Cellular component	• extracellular region • soluble fraction
Biological process	• regulation of cell growth • cell adhesion • signal transduction • cell-cell signaling • Wnt receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
134.2 – 134.24 Mb

Chr 15:
66.72 – 66.75 Mb

PubMed search

[1]

[2]

WNT1-inducible-signaling pathway protein 1 is a protein that in humans is encoded by the WISP1 gene.^[1]^[2]

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants.^[2]

References

^ Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, Watanabe C, Cohen RL, Melhem MF, Finley GG, Quirke P, Goddard AD, Hillan KJ, Gurney AL, Botstein D, Levine AJ (Jan 1999). "WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors". Proc Natl Acad Sci U S A 95 (25): 14717–22. doi:10.1073/pnas.95.25.14717. PMC 24515. PMID 9843955. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=24515.
^ ^a ^b "Entrez Gene: WISP1 WNT1 inducible signaling pathway protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8840.

Xu L, Corcoran RB, Welsh JW (2000). "WISP-1 is a Wnt-1- and beta-catenin-responsive oncogene.". Genes Dev. 14 (5): 585–95. PMC 316421. PMID 10716946. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316421.
Tanaka S, Sugimachi K, Saeki H (2001). "A novel variant of WISP1 lacking a Von Willebrand type C module overexpressed in scirrhous gastric carcinoma.". Oncogene 20 (39): 5525–32. doi:10.1038/sj.onc.1204723. PMID 11571650.
Desnoyers L, Arnott D, Pennica D (2002). "WISP-1 binds to decorin and biglycan.". J. Biol. Chem. 276 (50): 47599–607. doi:10.1074/jbc.M108339200. PMID 11598131.
Xie D, Nakachi K, Wang H (2002). "Elevated levels of connective tissue growth factor, WISP-1, and CYR61 in primary breast cancers associated with more advanced features.". Cancer Res. 61 (24): 8917–23. PMID 11751417.
Su F, Overholtzer M, Besser D, Levine AJ (2002). "WISP-1 attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase.". Genes Dev. 16 (1): 46–57. doi:10.1101/gad.942902. PMC 155313. PMID 11782444. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155313.
Saxena N, Banerjee S, Sengupta K (2002). "Differential expression of WISP-1 and WISP-2 genes in normal and transformed human breast cell lines.". Mol. Cell. Biochem. 228 (1-2): 99–104. doi:10.1023/A:1013338912642. PMID 11855747.
Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Soon LL, Yie TA, Shvarts A (2003). "Overexpression of WISP-1 down-regulated motility and invasion of lung cancer cells through inhibition of Rac activation.". J. Biol. Chem. 278 (13): 11465–70. doi:10.1074/jbc.M210945200. PMID 12529380.
Tanaka S, Sugimachi K, Kameyama T (2003). "Human WISP1v, a member of the CCN family, is associated with invasive cholangiocarcinoma.". Hepatology 37 (5): 1122–9. doi:10.1053/jhep.2003.50187. PMID 12717393.
Hocevar BA, Mou F, Rennolds JL (2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2).". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. PMC 162138. PMID 12805222. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=162138.
Gerhard DS, Wagner L, Feingold EA (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Cervello M, Giannitrapani L, Labbozzetta M (2005). "Expression of WISPs and of their novel alternative variants in human hepatocellular carcinoma cells.". Ann. N. Y. Acad. Sci. 1028: 432–9. doi:10.1196/annals.1322.051. PMID 15650268.
Nusbaum C, Mikkelsen TS, Zody MC (2006). "DNA sequence and analysis of human chromosome 8.". Nature 439 (7074): 331–5. doi:10.1038/nature04406. PMID 16421571.
Ewing RM, Chu P, Elisma F (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
Yanagita T, Kubota S, Kawaki H (2007). "Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes.". FEBS J. 274 (7): 1655–65. doi:10.1111/j.1742-4658.2007.05709.x. PMID 17381509.
Davies SR, Watkins G, Mansel RE, Jiang WG (2007). "Differential expression and prognostic implications of the CCN family members WISP-1, WISP-2, and WISP-3 in human breast cancer.". Ann. Surg. Oncol. 14 (6): 1909–18. doi:10.1245/s10434-007-9376-x. PMID 17406949.
Urano T, Narusawa K, Shiraki M (2007). "Association of a single nucleotide polymorphism in the WISP1 gene with spinal osteoarthritis in postmenopausal Japanese women.". J. Bone Miner. Metab. 25 (4): 253–8. doi:10.1007/s00774-007-0757-9. PMID 17593496.
Tian C, Zhou ZG, Meng WJ (2007). "Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients.". World J. Gastroenterol. 13 (28): 3878–82. PMID 17657846.
Yamashita T, Budhu A, Forgues M, Wang XW (2007). "Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma.". Cancer Res. 67 (22): 10831–9. doi:10.1158/0008-5472.CAN-07-0908. PMID 18006828.

WNT1-inducible-signaling pathway protein 1

References

Further reading