WIPF1

WAS/WASL interacting protein family, member 1

PDB rendering based on 2a41.

Available structures
PDB	2a41

Identifiers

Symbols

WIPF1; MGC111041; PRPL-2; WASPIP; WIP

External IDs

OMIM: 602357 MGI: 2178801 HomoloGene: 86891 GeneCards: WIPF1 Gene

Gene Ontology
Molecular function	• actin binding • protein binding • profilin binding
Cellular component	• cytoplasm • actin filament • actin cytoskeleton • cytoplasmic membrane-bounded vesicle
Biological process	• protein complex assembly • actin polymerization or depolymerization • actin cytoskeleton organization • actin filament-based movement • positive regulation of protein export from nucleus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
175.42 – 175.55 Mb

Chr 2:
73.27 – 73.37 Mb

PubMed search

[1]

[2]

WAS/WASL-interacting protein family member 1 is a protein that in humans is encoded by the WIPF1 gene.^[1]^[2]

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.^[2]

Interactions

WIPF1 has been shown to interact with Wiskott-Aldrich syndrome protein,^[1]^[3] Cortactin^[4] and NCK1.^[3]

References

^ ^a ^b Ramesh N, Anton IM, Hartwig JH, Geha RS (Feb 1998). "WIP, a protein associated with Wiskott–Aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells". Proc Natl Acad Sci U S A 94 (26): 14671–6. doi:10.1073/pnas.94.26.14671. PMC 25088. PMID 9405671. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25088.
^ ^a ^b "Entrez Gene: WIPF1 WAS/WASL interacting protein family, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7456.
^ ^a ^b Antón, I M; Lu W, Mayer B J, Ramesh N, Geha R S (Aug. 1998). "The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck". J. Biol. Chem. (UNITED STATES) 273 (33): 20992–5. doi:10.1074/jbc.273.33.20992. ISSN 0021-9258. PMID 9694849.
^ Kinley, Andrew W; Weed Scott A, Weaver Alissa M, Karginov Andrei V, Bissonette Eric, Cooper John A, Parsons J Thomas (Mar. 2003). "Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion". Curr. Biol. (England) 13 (5): 384–93. doi:10.1016/S0960-9822(03)00107-6. ISSN 0960-9822. PMID 12620186.

Ramesh N, Antón IM, Martínez-Quiles N, Geha RS (1999). "Waltzing with WASP". Trends Cell Biol. 9 (1): 15–9. doi:10.1016/S0962-8924(98)01411-1. PMID 10087612.
Antón IM, Lu W, Mayer BJ et al. (1998). "The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck". J. Biol. Chem. 273 (33): 20992–5. doi:10.1074/jbc.273.33.20992. PMID 9694849.
Stewart DM, Tian L, Nelson DL (1999). "Mutations that cause the Wiskott-Aldrich syndrome impair the interaction of Wiskott-Aldrich syndrome protein (WASP) with WASP interacting protein". J. Immunol. 162 (8): 5019–24. PMID 10202051.
Vaduva G, Martinez-Quiles N, Anton IM et al. (1999). "The human WASP-interacting protein, WIP, activates the cell polarity pathway in yeast". J. Biol. Chem. 274 (24): 17103–8. doi:10.1074/jbc.274.24.17103. PMID 10358064.
Moreau V, Frischknecht F, Reckmann I et al. (2000). "A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization". Nat. Cell Biol. 2 (7): 441–8. doi:10.1038/35017080. PMID 10878810.
Vetterkind S, Miki H, Takenawa T et al. (2002). "The rat homologue of Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation". J. Biol. Chem. 277 (1): 87–95. doi:10.1074/jbc.M104555200. PMID 11687573.
Antón IM, de la Fuente MA, Sims TN et al. (2002). "WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation". Immunity 16 (2): 193–204. doi:10.1016/S1074-7613(02)00268-6. PMID 11869681.
Scott MP, Zappacosta F, Kim EY et al. (2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". J. Biol. Chem. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Benesch S, Lommel S, Steffen A et al. (2002). "Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2". J. Biol. Chem. 277 (40): 37771–6. doi:10.1074/jbc.M204145200. PMID 12147689.
Zettl M, Way M (2003). "The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs". Curr. Biol. 12 (18): 1617–22. doi:10.1016/S0960-9822(02)01112-0. PMID 12372256.
Volkman BF, Prehoda KE, Scott JA et al. (2002). "Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome". Cell 111 (4): 565–76. doi:10.1016/S0092-8674(02)01076-0. PMID 12437929.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Sasahara Y, Rachid R, Byrne MJ et al. (2003). "Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation". Mol. Cell 10 (6): 1269–81. doi:10.1016/S1097-2765(02)00728-1. PMID 12504004.
Luthi JN, Gandhi MJ, Drachman JG (2003). "X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP)". Exp. Hematol. 31 (2): 150–8. doi:10.1016/S0301-472X(02)01023-8. PMID 12591280.
Kinley AW, Weed SA, Weaver AM et al. (2003). "Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion". Curr. Biol. 13 (5): 384–93. doi:10.1016/S0960-9822(03)00107-6. PMID 12620186.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kim MK, Kim ES, Kim DS et al. (2004). "Two novel mutations of Wiskott-Aldrich syndrome: the molecular prediction of interaction between the mutated WASP L101P with WASP-interacting protein by molecular modeling". Biochim. Biophys. Acta 1690 (2): 134–40. doi:10.1016/j.bbadis.2004.06.007. PMID 15469902.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.

PDB gallery

2a41: Ternary complex of the WH2 Domain of WIP with Actin-DNAse I

WIPF1

Interactions

References

Further reading