WAPAL

Wings apart-like homolog (Drosophila)

Identifiers

WAPAL; FOE; KIAA0261; WAPL

External IDs

OMIM: 610754 MGI: 2675859 HomoloGene: 41002 GeneCards: WAPAL Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• chromatin • synaptonemal complex • nucleus • chromosome • cytoplasm • cohesin complex
Biological process	• cell cycle • mitosis • negative regulation of DNA replication • response to toxin • negative regulation of chromatin binding • interspecies interaction between organisms • negative regulation of sister chromatid cohesion • cell division • protein localization to chromatin • regulation of cohesin localization to chromatin
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
88.2 – 88.28 Mb

Chr 14:
35.49 – 35.56 Mb

PubMed search

[1]

[2]

Wings apart-like protein homolog is a protein that in humans is encoded by the WAPAL gene.^[1]^[2]^[3]

References

^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
^ Gandhi R, Gillespie PJ, Hirano T (Dec 2006). "Human Wapl Is a Cohesin-binding Protein that Promotes Sister Chromatid Resolution in Mitotic Prophase". Curr Biol 16 (24): 2406–17. doi:10.1016/j.cub.2006.10.061. PMC 1850625. PMID 17112726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850625.
^ "Entrez Gene: WAPAL wings apart-like homolog (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23063.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Oikawa K, Ohbayashi T, Kiyono T, et al. (2004). "Expression of a novel human gene, human wings apart-like (hWAPL), is associated with cervical carcinogenesis and tumor progression". Cancer Res. 64 (10): 3545–9. doi:10.1158/0008-5472.CAN-03-3822. PMID 15150110.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Kwiatkowski BA, Ragoczy T, Ehly J, Schubach WH (2004). "Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2". Exp. Cell Res. 300 (1): 223–33. doi:10.1016/j.yexcr.2004.06.028. PMID 15383329.
Kuroda M, Oikawa K, Ohbayashi T, et al. (2005). "A dioxin sensitive gene, mammalian WAPL, is implicated in spermatogenesis". FEBS Lett. 579 (1): 167–72. doi:10.1016/j.febslet.2004.11.070. PMID 15620708.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Kueng S, Hegemann B, Peters BH, et al. (2007). "Wapl controls the dynamic association of cohesin with chromatin". Cell 127 (5): 955–67. doi:10.1016/j.cell.2006.09.040. PMID 17113138.
Ohbayashi T, Oikawa K, Yamada K, et al. (2007). "Unscheduled overexpression of human WAPL promotes chromosomal instability". Biochem. Biophys. Res. Commun. 356 (3): 699–704. doi:10.1016/j.bbrc.2007.03.037. PMID 17382297.

WAPAL

References

Further reading