| Vulvar intraepithelial neoplasia | |
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| Classification and external resources | |
Micrograph of vulvar intraepithelial neoplasia III. H&E stain. |
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| ICD-10 | D07 (ILDS D07.120) |
| ICD-9 | 233.32 |
The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that covers the vulva. VIN is not cancer, and in some women it disappears without treatment. If the changes become more severe, there is a chance that cancer might develop after many years, and so it is referred to as a precancerous condition.[1]
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Medically speaking, the term denotes a squamous intraepithelial lesion of the vulva that shows dysplasia with varying degrees of atypia. The epithelial basement membrane is intact and the lesion is thus not invasive but has invasive potential.
The terminology of VIN evolved over several decades. In 1989[2] the Committee on Terminology, International Society for the Study of Vulvar Disease (ISSVD) replaced older terminology such as vulvar dystrophy, Bowen's disease, and Kraurosis vulvae by a new classification system for Epithelial Vulvar Disease:
Infection with Human Papillomavirus (HPV) is associated with developing VIN.
The patient may have no symptoms, or local symptomatology including itching, burning, and pain. The diagnosis is always based on a careful inspection and a targeted biopsy.
Vaccinating girls with HPV vaccine before their initial sexual contact has been shown to reduce incidence of VIN.[3]
The treatment of VIN is local to wide excision, in case of very extensive involvement or recurrency even a simple vulvectomy. Laser therapy has also been useful for VIN.
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