Veratridine

Veratridine

Other names Veratrine 3-Veratroylveracevine
Identifiers
CAS number	71-62-5^Y
PubChem	6280
ChemSpider	16498858^Y
ChEMBL	CHEMBL451227
IUPHAR ligand	2626
Jmol-3D images	Image 1
SMILES COc1ccc(cc1OC)C(=O)OC6CC[C@@]8(C)C7CC[C@@H]3[C@@]8(C[C@@]4(O)[C@@H]5CN2C[C@@H](C)CC[C@H]2[C@@](C)(O)[C@@]5(O)[C@@H](O)C[C@@]34O)O[C@]67O
InChI InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23?,24-,25-,26-,27-,28?,30-,31+,32+,33+,34+,35-,36-/m0/s1^Y Key: FVECELJHCSPHKY-XHAQNIINSA-N^Y InChI=1/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23?,24-,25-,26-,27-,28?,30-,31+,32+,33+,34+,35-,36-/m0/s1 Key: FVECELJHCSPHKY-XHAQNIINBL
Properties
Molecular formula	C₃₆H₅₁NO₁₁
Molar mass	673.79 g/mol
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Veratridine is a steroid-derived alkaloid from the family of Liliaceae that functions as a neurotoxin by activating sodium ion channels. It is a derivative of veracevine. It is primarily obtained from the herb Veratrum and sabadilla seeds. It binds to intramembrane receptor site 2 and increases intracellular Ca²⁺ concentration. It acts by preferentially binding to activated Na⁺ channels causing persistent activation that leads to increased nerve excitability.

It is used in ointments for the treatment of neuralgia and rheumatoid pain.