Vangaindrano [vaŋɡeɳˈɖʐanʷ] is a city (commune urbaine) in Atsimo-Atsinanana Region, Madagascar.
The city is near the mouth of the Mananara river at the southern part of the east coast. It's connected to the north by national road RN 12. The road continues south but that section can't be used by ordinary vehicles, due to its bad condition and lack of bridges.