Vaccenyl acetate

11-cis-Vaccenyl acetate
Identifiers
CAS number 6186-98-7 Y
PubChem 5363286
Jmol-3D images Image 1
Properties
Molecular formula C20H38O2
Molar mass 310.51 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

11-cis-Vaccenyl acetate (cVA) is a volatile chemical compound that acts as a pheromone in Drosophila. It is the acetate ester of vaccenyl alcohol.

The odorant receptor subunit Or67d was shown to be necessary and sufficient for detection of cVA. Males that are mutant for Or67d start courting other males, whereas females that lack Or67d become less receptive towards males courting them.[1] The sensory neurons expressing Or67d send projections to the glomerulus DA1.[2] DA1 is one of the three glomeruli that is bigger in males than in females. Moreover, the projection neurons that connect to DA1 have sexually dimorphic arborizations in the higher brain centers (esp. lateral horn).

References

  1. ^ A. Kurtovic, A. Widmer, B. J. Dickson, Nature 446, 542 (2007).
  2. ^ Couto A, Alenius M, Dickson BJ.; Curr Biol. 2005 Sep 6;15(17):1535-47.