VUF-8430

VUF-8430
Preferred IUPAC name

2-[(Aminoiminomethyl)amino]ethyl carbamimidothioic acid ester
Identifiers
Abbreviations VUF-8430
CAS number 98021-17-1 N
PubChem 3063228
ChemSpider 2323820 Y
ChEMBL CHEMBL1196470 N
Jmol-3D images Image 1
Properties
Molecular formula C4H11N5S
Molar mass 161.23 g mol−1
Exact mass 161.073516067 g mol-1
log P -1.367
 N (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

VUF-8430 is a histamine agonist[1] selective for the H4 subtype.[2]

References

  1. ^ Smith FM, Haskelberg H, Tracey DJ, Moalem-Taylor G (2007). "Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury". Neuroimmunomodulation 14 (6): 317–25. doi:10.1159/000125048. PMID 18401194. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000125048. 
  2. ^ Lim, HD; Smits, RA; Bakker, RA; Van Dam, CM; De Esch, IJ; Leurs, R (2006). "Discovery of S-(2-guanidylethyl)-isothiourea (VUF 8430) as a potent nonimidazole histamine H4 receptor agonist.". Journal of medicinal chemistry 49 (23): 6650–1. doi:10.1021/jm060880d. PMID 17154494.