VPS28
Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene.[1]
This gene encodes a protein involved in endosomal sorting of cell surface receptors via a multivesicular body/late endosome pathway. The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved in the sorting of ubiquitinated proteins. The two other subunits of ESCRT-I are vesicular protein sorting 23, also known as tumor susceptibility gene 101 (TSG101), and vesicular protein sorting 37. Two alternative transcripts encoding different isoforms have been described. Additional alternative transcripts may exist but the proteins encoded by these transcripts have not been verified experimentally.[1]
Interactions
VPS28 has been shown to interact with TSG101.[2][3][4]
References
- ^ a b "Entrez Gene: VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51160.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ Stuchell, Melissa D; Garrus Jennifer E, Müller Barbara, Stray Kirsten M, Ghaffarian Sanaz, McKinnon Rena, Kräusslich Hans-Georg, Morham Scott G, Sundquist Wesley I (Aug. 2004). "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. (United States) 279 (34): 36059–71. doi:10.1074/jbc.M405226200. ISSN 0021-9258. PMID 15218037.
- ^ Bishop, N; Woodman P (Apr. 2001). "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. (United States) 276 (15): 11735–42. doi:10.1074/jbc.M009863200. ISSN 0021-9258. PMID 11134028.
Further reading
- Raiborg C, Rusten TE, Stenmark H (2004). "Protein sorting into multivesicular endosomes". Curr. Opin. Cell Biol. 15 (4): 446–55. doi:10.1016/S0955-0674(03)00080-2. PMID 12892785.
- Bishop N, Woodman P (2001). "TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes". J. Biol. Chem. 276 (15): 11735–42. doi:10.1074/jbc.M009863200. PMID 11134028.
- Suzuki H, Fukunishi Y, Kagawa I, et al. (2001). "Protein–Protein Interaction Panel Using Mouse Full-Length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311163.
- Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein–ubiquitin conjugates". J. Cell Biol. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMC 2173266. PMID 11916981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173266.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Martin-Serrano J, Zang T, Bieniasz PD (2003). "Role of ESCRT-I in Retroviral Budding". J. Virol. 77 (8): 4794–804. doi:10.1128/JVI.77.8.4794-4804.2003. PMC 152150. PMID 12663786. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152150.
- Tanzi GO, Piefer AJ, Bates P (2003). "Equine Infectious Anemia Virus Utilizes Host Vesicular Protein Sorting Machinery during Particle Release". J. Virol. 77 (15): 8440–7. doi:10.1128/JVI.77.15.8440-8447.2003. PMC 165230. PMID 12857913. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=165230.
- Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414–9. doi:10.1073/pnas.2133846100. PMC 218772. PMID 14519844. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=218772.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Stuchell MD, Garrus JE, Müller B, et al. (2005). "The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding". J. Biol. Chem. 279 (34): 36059–71. doi:10.1074/jbc.M405226200. PMID 15218037.
- Bache KG, Slagsvold T, Cabezas A, et al. (2005). "The Growth-Regulatory Protein HCRP1/hVps37A Is a Subunit of Mammalian ESCRT-I and Mediates Receptor Down-Regulation". Mol. Biol. Cell 15 (9): 4337–46. doi:10.1091/mbc.E04-03-0250. PMC 515363. PMID 15240819. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515363.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Eastman SW, Martin-Serrano J, Chung W, et al. (2005). "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding". J. Biol. Chem. 280 (1): 628–36. doi:10.1074/jbc.M410384200. PMID 15509564.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Hui EK, Barman S, Tang DH, et al. (2006). "YRKL Sequence of Influenza Virus M1 Functions as the L Domain Motif and Interacts with VPS28 and Cdc42". J. Virol. 80 (5): 2291–308. doi:10.1128/JVI.80.5.2291-2308.2006. PMC 1395382. PMID 16474136. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1395382.
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