FLT1

Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

PDB rendering based on 1flt.

Available structures
PDB	1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG

Identifiers

Symbols

FLT1; FLT; VEGFR1

External IDs

OMIM: 165070 MGI: 95558 HomoloGene: 20463 GeneCards: FLT1 Gene

EC number

2.7.10.1

Gene Ontology
Molecular function	• nucleotide binding • transmembrane receptor protein tyrosine kinase activity • receptor activity • vascular endothelial growth factor receptor activity • ATP binding • growth factor binding • identical protein binding
Cellular component	• extracellular region • extracellular space • nucleus • nucleolus • cytoplasm • Golgi apparatus • plasma membrane • plasma membrane • plasma membrane • integral to plasma membrane
Biological process	• activation of MAPKK activity • patterning of blood vessels • response to hypoxia • sprouting angiogenesis • regulation of smooth muscle contraction • transmembrane receptor protein tyrosine kinase signaling pathway • multicellular organismal development • female pregnancy • positive regulation of cell proliferation • cell differentiation • positive regulation of cell migration • intracellular receptor mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • vascular endothelial growth factor receptor signaling pathway • positive regulation of smooth muscle cell proliferation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 13:
28.87 – 29.07 Mb

Chr 5:
148.37 – 148.54 Mb

PubMed search

[1]

[2]

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.^[1]

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]^[2]

1 Interactions
2 See also
3 References
4 Further reading

Interactions

FLT1 has been shown to interact with PLCG1^[3] and Vascular endothelial growth factor B.^[4]^[5]

References

^ Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (May 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene 5 (4): 519–24. PMID 2158038.
^ "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321.
^ Cunningham, S A; Arrate M P, Brock T A, Waxham M N (Nov. 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochem. Biophys. Res. Commun. (UNITED STATES) 240 (3): 635–9. doi:10.1006/bbrc.1997.7719. ISSN 0006-291X. PMID 9398617.
^ Olofsson, B; Korpelainen E, Pepper M S, Mandriota S J, Aase K, Kumar V, Gunji Y, Jeltsch M M, Shibuya M, Alitalo K, Eriksson U (Sep. 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. ISSN 0027-8424. PMC 21705. PMID 9751730. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=21705.
^ Makinen, T; Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (Jul. 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". J. Biol. Chem. (UNITED STATES) 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. ISSN 0021-9258. PMID 10409677.

Petrova TV, Makinen T, Alitalo K (1999). "Signaling via vascular endothelial growth factor receptors.". Exp. Cell Res. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
Sato Y, Kanno S, Oda N et al. (2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Ann. N. Y. Acad. Sci. 902 (1): 201–5; discussion 205–7. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
Boyd AW, Lackmann M (2002). "Signals from Eph and ephrin proteins: a developmental tool kit". Sci. STKE 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
Luttun A, Tjwa M, Carmeliet P (2003). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Ann. N. Y. Acad. Sci. 979: 80–93. doi:10.1111/j.1749-6632.2002.tb04870.x. PMID 12543719.
Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia". Pediatr. Res. 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". Angiogenesis 9 (4): 225–30; discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
Widmer M, Villar J, Benigni A et al. (2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review". Obstetrics and gynecology 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
López-Novoa JM (2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia". Nephrol. Dial. Transplant. 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.
Poesen K, Lambrechts D et al. (2008). "Novel Role for Vascular Endothelial Growth Factor (VEGF)Receptor-1 and Its Ligand VEGF-B in Motor Neuron Degeneration". J. Neurosci. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.
Joukov V, Kaipainen A, Jeltsch M et al. (1997). "Vascular endothelial growth factors VEGF-B and VEGF-C". J. Cell. Physiol. 173 (2): 211–5. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
Rosandra N. Kaplan, Rebecca D. Riba et al. (2005). "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". Nature 438 (7069): 820–7. doi:10.1038/nature04186. PMC 2945882. PMID 16341007. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2945882.

PDB gallery

1flt: VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR

1qsv: THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES

1qsz: THE VEGF-BINDING DOMAIN OF FLT-1 (MINIMIZED MEAN)

1qty: VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR

1rv6: Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1

Protein kinases: tyrosine kinases (EC 2.7.10)

Receptor tyrosine kinases (EC 2.7.10.1)

Growth factor receptors

EGF receptor family	EGFR · ERBB2 · ERBB3 · ERBB4

Insulin receptor family	IGF1R · INSR · INSRR

PDGF receptor family	CSF1R · FLT3 · KIT · PDGFR (PDGFRA, PDGFRB)

FGF receptor family	FGFR1 · FGFR2 · FGFR3 · FGFR4

VEGF receptors family	VEGFR1 · VEGFR2 · VEGFR3 · VEGFR4

HGF receptor family	MET · RON

Trk receptor family	NTRK1 · NTRK2 · NTRK3

EPH receptor family

EPHA1 · EPHA2 · EPHA3 · EPHA4 · EPHA5 · EPHA6 · EPHA7 · EPHA8 · EPHB1 · EPHB2 · EPHB3 · EPHB4 · EPHB5 · EPHB6 · EPHX

LTK receptor family

LTK · ALK

TIE receptor family

TIE · TEK

ROR receptor family

ROR1 · ROR2

DDR receptor family

DDR1 · DDR2

PTK7 receptor family

RYK receptor family

MuSK receptor family

ROS receptor family

AATYK receptor family

AATYK · AATYK2 · AATYK3

AXL receptor family

AXL · MER · TYRO3

RET receptor family

RET

uncatagorised

STYK1

Non-receptor tyrosine kinases (EC 2.7.10.2)

ABL family	ABL1 · ARG

ACK family	ACK1 · TNK1

CSK family	CSK · MATK

FAK family	FAK · PYK2

FES family	FES · FER

FRK family	FRK · BRK · SRMS

JAK family	JAK1 · JAK2 · JAK3 · TYK2

SRC-A family	SRC · FGR · FYN · YES1

SRC-B family	BLK · HCK · LCK · LYN

TEC family	TEC · BMX · BTK · ITK · TXK

SYK family	SYK · ZAP70

B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6

Receptors: growth factor receptors

Type I cytokine receptor	Nerve growth factors: Ciliary neurotrophic factor Erythropoietin

Receptor protein serine/threonine kinase	TGF pathway: TGF-beta (1, 2) · Activin (1, 2) · Bone morphogenetic protein (1, 2)

Receptor tyrosine kinase	Fibroblast growth factor (1, 2, 3, 4) Nerve growth factors: high affinity Trk (TrkA, TrkB, TrkC) Hepatocyte growth factor Somatomedin (Insulin-like growth factor 1) ErbB/Epidermal growth factor VEGF (1, 2, 3)

Tumor necrosis factor receptor	Nerve growth factors: Low affinity/p75

Ig superfamily	Platelet-derived growth factor (A, B) Stem cell factor

Other/ungrouped	Somatomedin (Insulin-like growth factor 2)

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

FLT1

Contents

Interactions

See also

References

Further reading