| Variable charge, X-linked | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | VCX; MGC118975; VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1 | ||||||||||||
| External IDs | OMIM: 300229 HomoloGene: 88395 GeneCards: VCX Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 26609 | n/a | |||||||||||
| Ensembl | ENSG00000182583 | n/a | |||||||||||
| UniProt | Q9H320 | n/a | |||||||||||
| RefSeq (mRNA) | NM_013452 | n/a | |||||||||||
| RefSeq (protein) | NP_038480 | n/a | |||||||||||
| Location (UCSC) | Chr X: 7.81 – 7.81 Mb |
n/a | |||||||||||
| PubMed search | [1] | n/a | |||||||||||
Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.[1][2][3]
This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.[3]