VARS

Valyl-tRNA synthetase

Identifiers

VARS; G7A; VARS1; VARS2

External IDs

OMIM: 192150 MGI: 90675 HomoloGene: 4587 GeneCards: VARS Gene

6.1.1.9

Gene Ontology
Molecular function	• nucleotide binding • valine-tRNA ligase activity • valine-tRNA ligase activity • protein binding • ATP binding • ligase activity
Cellular component	• intracellular • cytoplasm • mitochondrion • cytosol
Biological process	• translational elongation • tRNA aminoacylation for protein translation • valyl-tRNA aminoacylation • gene expression
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr c6_COX:
31.88 – 31.9 Mb

Chr 17:
35.14 – 35.15 Mb

PubMed search

[1]

[2]

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene.^[1]^[2]

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.^[2]

References

^ Bonnefond L, Fender A, Rudinger-Thirion J, Giege R, Florentz C, Sissler M (Mar 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907.
^ ^a ^b "Entrez Gene: VARS valyl-tRNA synthetase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7407.

Hsieh SL, Campbell RD (1991). "Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase.". Biochem. J. 278 ( Pt 3): 809–16. PMC 1151418. PMID 1898367. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1151418.
Sargent CA, Dunham I, Campbell RD (1989). "Identification of multiple HTF-island associated genes in the human major histocompatibility complex class III region.". EMBO J. 8 (8): 2305–12. PMC 401163. PMID 2477242. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=401163.
Bec G, Kerjan P, Zha XD, Waller JP (1990). "Valyl-tRNA synthetase from rabbit liver. I. Purification as a heterotypic complex in association with elongation factor 1.". J. Biol. Chem. 264 (35): 21131–7. PMID 2556394.
Motorin YuA , Wolfson AD, Orlovsky AF, Gladilin KL (1988). "Mammalian valyl-tRNA synthetase forms a complex with the first elongation factor.". FEBS Lett. 238 (2): 262–4. doi:10.1016/0014-5793(88)80492-7. PMID 3169261.
Bec G, Kerjan P, Waller JP (1994). "Reconstitution in vitro of the valyl-tRNA synthetase-elongation factor (EF) 1 beta gamma delta complex. Essential roles of the NH2-terminal extension of valyl-tRNA synthetase and of the EF-1 delta subunit in complex formation.". J. Biol. Chem. 269 (3): 2086–92. PMID 8294461.
Vilalta A, Donovan D, Wood L, et al. (1993). "Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.". Gene 123 (2): 181–6. doi:10.1016/0378-1119(93)90122-J. PMID 8428657.
Motorin Y (1996). "Two human valyl-tRNA synthetase-encoding cDNA sequences deposited in GenBank display extensive differences.". Gene 170 (2): 289–91. doi:10.1016/0378-1119(96)84699-3. PMID 8666263.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403804.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Jiang S, Wolfe CL, Warrington JA, Norcum MT (2005). "Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit.". FEBS Lett. 579 (27): 6049–54. doi:10.1016/j.febslet.2005.09.062. PMID 16229838.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

VARS

See also

References

Further reading