Chemotherapy regimens

A fundamental philosophy of combination cancer therapy is that different drugs work through different cytotoxic mechanisms. Because they have different dose-limiting adverse effects, they can be given together at full doses in chemotherapy regimens.^[1]

The term "induction regimen" refers to a chemotherapy regimen which is used for the initial treatment of a disease.

Chemotherapy regimens are often identified by acronyms, identifying the agents used in combination. However, the letters used are not consistent across regimens, and in some cases (for example, "BEACOPP") the same letter combination is used to represent two different treatments: there is not a naming standard for chemotherapy regimens. This page merely lists commonly used conventions.

Name	Components	Example of uses, and other notes
ABVD	Adriamycin (doxorubicin), bleomycin, vinblastine, dacarbazine	Hodgkin's lymphoma
AC	Adriamycin (doxorubicin), cyclophosphamide	Breast cancer
BEACOPP	Bleomycin, etoposide, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), procarbazine, prednisone	Hodgkin's lymphoma
BEP	Bleomycin, etoposide, platinum agent (cisplatin)	Testicular cancer, germ cell tumors
CA	Cyclophosphamide, Adriamycin (doxorubicin) (same as AC)	Breast cancer
CAF	Cyclophosphamide, Adriamycin (doxorubicin), fluorouracil (5-FU)	Breast cancer
CAV	Cyclophosphamide, Adriamycin (doxorubicin), vincristine	Lung cancer
CBV	Cyclophosphamide, BCNU (carmustine), VP-16 (etoposide)	Lymphoma
ChlVPP/EVA	Chlorambucil, vincristine (Oncovin), procarbazine, prednisone, etoposide, vinblastine, Adriamycin (doxorubicin)	Hodgkin's lymphoma
CHOP	Cyclophosphamide, hydroxydoxorubicin (doxorubicin), vincristine (Oncovin), prednisone	Non-Hodgkin lymphoma
CHOP-R or R-CHOP	CHOP + rituximab	B cell non-Hodgkin lymphoma
COP or CVP	Cyclophosphamide, Oncovin (vincristine), prednisone	Non-Hodgkin lymphoma in patients with history of cardiovascular disease
CMF	Cyclophosphamide, methotrexate, fluorouracil (5-FU)	Breast cancer
COPP	Cyclophosphamide, Oncovin (vincristine), procarbazine, prednisone	Non-Hodgkin lymphoma
CVAD / HyperCVAD	Cyclophosphamide, Vincristine, Adriamycin (doxorubicin), dexamethasone	Aggressive non-Hodgkin lymphoma, lymphoblastic lymphoma, some forms of leukemia
EC	Epirubicin, cyclophosphamide	Breast cancer
ECF	Epirubicin, cisplatin, fluorouracil (5-FU)	Gastric cancer and oesophageal cancer
EP	Etoposide, platinum agent (cisplatin)	Testicular cancer, germ cell tumors
EPOCH	Etoposide, prednisone, Oncovin, cyclophosphamide, and hydroxydaunorubicin	Lymphomas
FEC	Fluorouracil (5-FU), epirubicin, cyclophosphamide	Breast cancer
FL (Also known as Mayo)	Fluorouracil (5-FU), leucovorin (folinic acid)	Colorectal cancer
FOLFOX	Fluorouracil (5-FU), leucovorin (folinic acid), oxaliplatin	Colorectal cancer
FOLFIRI	Fluorouracil (5-FU), leucovorin (folinic acid), irinotecan	Colorectal cancer
ICE	ifosfamide, carboplatin, etoposide (VP-16)	Aggressive lymphomas, progressive neuroblastoma
ICE-R	ICE + rituximab	High-risk progressive or recurrent lymphomas
m-BACOD	Methotrexate, bleomycin, Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), dexamethasone	Non-Hodgkin lymphoma
MACOP-B	Methotrexate, leucovorin (folinic acid), Adriamycin (doxorubicin), cyclophosphamide, Oncovin (vincristine), prednisone, bleomycin	Non-Hodgkin lymphoma
MOPP	Mechlorethamine, Oncovin (vincristine), procarbazine, prednisone	Hodgkin's lymphoma
MVAC	methotrexate, vinblastine, adriamycin, cisplatin	Advanced bladder cancer^[2]
PCV	Procarbazine, CCNU (lomustine), vincristine	Brain tumors
ProMACE-MOPP	Methotrexate, Adriamycin (doxorubicin), cyclophosphamide, etoposide + MOPP	Non-Hodgkin lymphoma
ProMACE-CytaBOM	Prednisone, doxorubicin (adriamycin), cyclophosphamide, etoposide, cytarabine, bleomycin, Oncovin (vincristine), methotrexate, leucovorin	Non-Hodgkin lymphoma
R-FCM	Rituximab, fludarabine, cyclophosphamide, mitoxantrone	B cell non-Hodgkin lymphoma
Stanford V	Doxorubicin, mechlorethamine, bleomycin, vinblastine, vincristine, etoposide, prednisone	Hodgkin's lymphoma
Thal/Dex	Thalidomide, dexamethasone	Multiple myeloma
TIP	Paclitaxel, ifosfamide, platinum agent cisplatin	Testicular cancer, germ cell tumors in salvage therapy
VAC	Vincristine, Actinomycin, Cyclophosphamide	Rhabdomyosarcoma
VAD	Vincristine, Adriamycin (doxorubicin), dexamethasone	Multiple myeloma
VAMP	Vincristine and others	Hodgkin's lymphoma, leukemia, multiple myeloma
VAPEC-B	Vincristine, Adriamycin (doxorubicin), prednisone, etoposide, cyclophosphamide, bleomycin	Hodgkin's lymphoma
VIP	Vinblastin, ifosfamide, platinum agent cisplatin	Testicular cancer, germ cell tumors

References

^ Mayer, RJ, Targeted therapy for advanced colorectal cancer -- more is not always better, N Engl J Med. 2009;360:623
^ http://www.cancernetwork.com/bladder-cancer/content/article/10165/71963

External links

Intracellular chemotherapeutic agents/antineoplastic agents (L01)

SPs/MIs
(M phase)

Block microtubule assembly	Vinca alkaloids (Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine)

Block microtubule disassembly	Taxanes (Cabazitaxel, Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel) • Epothilones (Ixabepilone)

DNA replication
inhibitor

DNA precursors/
antimetabolites
(S phase)

Folic acid	dihydrofolate reductase inhibitor (Aminopterin, Methotrexate, Pemetrexed, Pralatrexate) • thymidylate synthase inhibitor (Raltitrexed, Pemetrexed)

Purine	adenosine deaminase inhibitor (Pentostatin) halogenated/ribonucleotide reductase inhibitors (Cladribine, Clofarabine, Fludarabine) thiopurine (Thioguanine, Mercaptopurine)

Pyrimidine	thymidylate synthase inhibitor (Fluorouracil, Capecitabine, Tegafur, Carmofur, Floxuridine) DNA polymerase inhibitor (Cytarabine) ribonucleotide reductase inhibitor (Gemcitabine) hypomethylating agent (Azacitidine, Decitabine)

Deoxyribonucleotide	ribonucleotide reductase inhibitor (Hydroxycarbamide)

Topoisomerase inhibitors
(S phase)

I	Camptotheca (Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan)

II	Podophyllum (Etoposide, Teniposide)

II+Intercalation	Anthracyclines (Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pirarubicin, Valrubicin, Zorubicin) • Anthracenediones (Mitoxantrone, Pixantrone)

Crosslinking of DNA
(CCNS)

Alkylating	Nitrogen mustards: Mechlorethamine • Cyclophosphamide (Ifosfamide, Trofosfamide) • Chlorambucil (Melphalan, Prednimustine) • Bendamustine • Uramustine • Estramustine Nitrosoureas: Carmustine • Lomustine (Semustine) • Fotemustine • Nimustine • Ranimustine • Streptozocin Alkyl sulfonates: Busulfan (Mannosulfan, Treosulfan) Aziridines: Carboquone • ThioTEPA • Triaziquone • Triethylenemelamine

Alkylating-like	Platinum (Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin)

Nonclassical	Hydrazines (Procarbazine) • Triazenes (Dacarbazine, Temozolomide) • Altretamine • Mitobronitol

Intercalation	Streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin)

Photosensitizers/PDT

Aminolevulinic acid/Methyl aminolevulinate • Efaproxiral • Porphyrin derivatives (Porfimer sodium, Talaporfin, Temoporfin, Verteporfin)

Other

Enzyme inhibitors	FI (Tipifarnib) • CDK inhibitors (Alvocidib, Seliciclib) • PrI (Bortezomib) • PhI (Anagrelide) • IMPDI (Tiazofurine) • LI (Masoprocol) • PARP inhibitor (Olaparib) • HDAC (Panobinostat, Vorinostat, Romidepsin)

Receptor antagonists	ERA (Atrasentan) • retinoid X receptor (Bexarotene) • sex steroid (Testolactone)

Other/ungrouped	Amsacrine • Trabectedin • retinoids (Alitretinoin, Tretinoin) • Arsenic trioxide • asparagine depleters (Asparaginase/Pegaspargase) • Celecoxib • Demecolcine • Elesclomol • Elsamitrucin • Etoglucid • Lonidamine • HAMLET (human alpha-lactalbumin made lethal to tumor cells) • Lucanthone • Mitoguazone • Mitotane • Oblimersen • Omacetaxine mepesuccinate • mTOR inhibitors (Everolimus, Temsirolimus)

M: NEO

tsoc, mrkr

tumr, epon, para

drug (L1i/1e/V03)

Chemotherapy regimens

See also

References

External links