Ubiquitin A-52 residue ribosomal protein fusion product 1

PDB rendering based on 1aar.

Available structures
PDB	1aar, 1cmx, 1d3z, 1f9j, 1fxt, 1g6j, 1gjz, 1nbf, 1ogw, 1otr, 1p3q, 1q0w, 1q5w, 1s1q, 1sif, 1tbe, 1ubi, 1ubq, 1ud7, 1uzx, 1v80, 1v81, 1wr1, 1wr6, 1wrd, 1xd3, 1xqq, 1yd8, 1yiw, 1yj1, 1yx5, 1yx6, 1zgu, 2ayo, 2bgf, 2c7m, 2c7n, 2d3g, 2den, 2dx5, 2fcm, 2fcn, 2fcq, 2fcs, 2fid, 2fif, 2fuh, 2g3q, 2g45, 2gbj, 2gbk, 2gbm, 2gbn, 2gbr, 2gmi, 2hd5, 2hth, 2ibi, 2j7q, 2nr2, 2o6v, 2oob

Identifiers

Symbols

UBA52; CEP52; HUBCEP52; L40; MGC126879; MGC126881; MGC57125; RPL40

External IDs

OMIM: 191321 HomoloGene: 68307 GeneCards: UBA52 Gene

Gene Ontology
Molecular function	• structural constituent of ribosome • protein binding
Cellular component	• nucleus • nucleoplasm • nucleoplasm • cytoplasm • cytosol • cytosol • ribosome • plasma membrane • endosome membrane • endosome membrane • endocytic vesicle membrane
Biological process	• cell cycle checkpoint • G1/S transition of mitotic cell cycle • S phase of mitotic cell cycle • activation of MAPK activity • M/G1 transition of mitotic cell cycle • mitotic cell cycle • toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-dependent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • MyD88-independent toll-like receptor signaling pathway • DNA repair • translation • translational elongation • translational termination • protein modification process • apoptosis • apoptosis • anti-apoptosis • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • epidermal growth factor receptor signaling pathway • I-kappaB kinase/NF-kappaB cascade • JNK cascade • Toll signaling pathway • induction of apoptosis by extracellular signals • gene expression • viral reproduction • cellular membrane organization • RNA metabolic process • mRNA metabolic process • endosome transport • viral infectious cycle • viral transcription • endocrine pancreas development • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process • negative regulation of type I interferon production • toll-like receptor 1 signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 3 signaling pathway • toll-like receptor 4 signaling pathway • negative regulation of epidermal growth factor receptor signaling pathway • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • cellular protein metabolic process • innate immune response • nerve growth factor receptor signaling pathway • T cell receptor signaling pathway • positive regulation of NF-kappaB transcription factor activity • stress-activated MAPK cascade • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_001033930.1

n/a

RefSeq (protein)

NP_001029102.1

n/a

Location (UCSC)

Chr 19:
18.68 – 18.69 Mb

n/a

PubMed search

[1]

n/a

60S ribosomal protein L40 is a protein that in humans is encoded by the UBA52 gene.^[1]^[2]

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.^[2]

References

^ Webb GC, Baker RT, Coggan M, Board PG (Jun 1994). "Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12". Genomics 19 (3): 567–9. doi:10.1006/geno.1994.1108. PMID 8188300.
^ ^a ^b "Entrez Gene: UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7311.

Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins.". Biochem. Cell Biol. 73 (11-12): 933–47. doi:10.1139/o95-101. PMID 8722009.
Murphey RK, Godenschwege TA (2002). "New roles for ubiquitin in the assembly and function of neuronal circuits.". Neuron 36 (1): 5–8. doi:10.1016/S0896-6273(02)00943-1. PMID 12367500.
Baker RT, Board PG (1992). "The human ubiquitin/52-residue ribosomal protein fusion gene subfamily (UbA52) is composed primarily of processed pseudogenes.". Genomics 14 (2): 520–2. doi:10.1016/S0888-7543(05)80258-7. PMID 1330885.
Baker RT, Board PG (1991). "The human ubiquitin-52 amino acid fusion protein gene shares several structural features with mammalian ribosomal protein genes.". Nucleic Acids Res. 19 (5): 1035–40. doi:10.1093/nar/19.5.1035. PMC 333777. PMID 1850507. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=333777.
Monia BP, Ecker DJ, Jonnalagadda S, et al. (1989). "Gene synthesis, expression, and processing of human ubiquitin carboxyl extension proteins.". J. Biol. Chem. 264 (7): 4093–103. PMID 2537304.
Lund PK, Moats-Staats BM, Simmons JG, et al. (1985). "Nucleotide sequence analysis of a cDNA encoding human ubiquitin reveals that ubiquitin is synthesized as a precursor.". J. Biol. Chem. 260 (12): 7609–13. PMID 2581967.
Salvesen G, Lloyd C, Farley D (1987). "cDNA encoding a human homolog of yeast ubiquitin 1.". Nucleic Acids Res. 15 (13): 5485. doi:10.1093/nar/15.13.5485. PMC 305980. PMID 3037496. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=305980.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column.". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Cook WJ, Jeffrey LC, Kasperek E, Pickart CM (1994). "Structure of tetraubiquitin shows how multiubiquitin chains can be formed.". J. Mol. Biol. 236 (2): 601–9. doi:10.1006/jmbi.1994.1169. PMID 8107144.
Vadlamudi RK, Joung I, Strominger JL, Shin J (1996). "p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins.". J. Biol. Chem. 271 (34): 20235–7. doi:10.1074/jbc.271.34.20235. PMID 8702753.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes.". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
Cruz C, Ventura F, Bartrons R, Rosa JL (2001). "HERC3 binding to and regulation by ubiquitin.". FEBS Lett. 488 (1-2): 74–80. doi:10.1016/S0014-5793(00)02371-1. PMID 11163799.
Lee TA, Tyers M (2002). "Ubiquitin junction, what's your function?". Genome Biol. 2 (10): REPORTS4025. doi:10.1186/gb-2001-2-10-reports4025. PMC 138970. PMID 11597332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=138970.
Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes.". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155282.
Bishop N, Horman A, Woodman P (2002). "Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.". J. Cell Biol. 157 (1): 91–101. doi:10.1083/jcb.200112080. PMC 2173266. PMID 11916981. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

PDB gallery

1aar: STRUCTURE OF A DIUBIQUITIN CONJUGATE AND A MODEL FOR INTERACTION WITH UBIQUITIN CONJUGATING ENZYME (E2)

1cmx: STRUCTURAL BASIS FOR THE SPECIFICITY OF UBIQUITIN C-TERMINAL HYDROLASES

1d3z: UBIQUITIN NMR STRUCTURE

1f9j: STRUCTURE OF A NEW CRYSTAL FORM OF TETRAUBIQUITIN

1fxt: STRUCTURE OF A CONJUGATING ENZYME-UBIQUITIN THIOLESTER COMPLEX

1g6j: STRUCTURE OF RECOMBINANT HUMAN UBIQUITIN IN AOT REVERSE MICELLES

1gjz: SOLUTION STRUCTURE OF A DIMERIC N-TERMINAL FRAGMENT OF HUMAN UBIQUITIN

1nbf: Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

1ogw: SYNTHETIC UBIQUITIN WITH FLUORO-LEU AT 50 AND 67

1otr: Solution Structure of a CUE-Ubiquitin Complex

1p3q: Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9

1q0w: Solution structure of Vps27 amino-terminal UIM-ubiquitin complex

1q5w: Ubiquitin Recognition by Npl4 Zinc-Fingers

1s1q: TSG101(UEV) domain in complex with Ubiquitin

1sif: Crystal structure of a multiple hydrophobic core mutant of ubiquitin

1tbe: STRUCTURE OF TETRAUBIQUITIN SHOWS HOW MULTIUBIQUITIN CHAINS CAN BE FORMED

1ubi: SYNTHETIC STRUCTURAL AND BIOLOGICAL STUDIES OF THE UBIQUITIN SYSTEM. PART 1

1ubq: STRUCTURE OF UBIQUITIN REFINED AT 1.8 ANGSTROMS RESOLUTION

1ud7: SOLUTION STRUCTURE OF THE DESIGNED HYDROPHOBIC CORE MUTANT OF UBIQUITIN, 1D7

1uzx: A COMPLEX OF THE VPS23 UEV WITH UBIQUITIN

1v80: Solution structures of ubiquitin at 30 bar and 3 kbar

1v81: Solution structures of ubiquitin at 30 bar and 3 kbar

1wr1: The complex sturcture of Dsk2p UBA with ubiquitin

1wr6: Crystal structure of GGA3 GAT domain in complex with ubiquitin

1wrd: Crystal structure of Tom1 GAT domain in complex with ubiquitin

1xd3: Crystal structure of UCHL3-UbVME complex

1xqq: Simultaneous determination of protein structure and dynamics

1yd8: COMPLEX OF HUMAN GGA3 GAT DOMAIN AND UBIQUITIN

1yiw: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin

1yj1: X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin

1yx5: Solution Structure of S5a UIM-1/Ubiquitin Complex

1yx6: Solution Structure of S5a UIM-2/Ubiquitin Complex

1zgu: Solution structure of the human Mms2-Ubiquitin complex

2ayo: Structure of USP14 bound to ubquitin aldehyde

2bgf: NMR STRUCTURE OF LYS48-LINKED DI-UBIQUITIN USING CHEMICAL SHIFT PERTURBATION DATA TOGETHER WITH RDCS AND 15N-RELAXATION DATA

2c7m: HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN

2c7n: HUMAN RABEX-5 RESIDUES 1-74 IN COMPLEX WITH UBIQUITIN

2d3g: Double sided ubiquitin binding of Hrs-UIM

2den: Solution Structure of the Ubiquitin-Associated Domain of Human BMSC-UbP and its Complex with Ubiquitin

2dx5: The complex structure between the mouse EAP45-GLUE domain and ubiquitin

2fcm: X-ray Crystal Structure of a Chemically Synthesized [D-Gln35]Ubiquitin with a Cubic Space Group

2fcn: X-ray Crystal Structure of a Chemically Synthesized [D-Val35]Ubiquitin with a Cubic Space Group

2fcq: X-ray Crystal Structure of a Chemically Synthesized Ubiquitin with a Cubic Space Group

2fcs: X-ray Crystal Structure of a Chemically Synthesized [L-Gln35]Ubiquitin with a Cubic Space Group

2fid: Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin

2fif: Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin

2fuh: Solution Structure of the UbcH5c/Ub Non-covalent Complex

2g3q: Solution Structure of Ede1 UBA-ubiquitin complex

2g45: Co-crystal structure of znf ubp domain from the deubiquitinating enzyme isopeptidase T (isot) in complex with ubiquitin

2gbj: Crystal Structure of the 9-10 8 Glycine Insertion Mutant of Ubiquitin.

2gbk: Crystal Structure of the 9-10 MoaD Insertion Mutant of Ubiquitin

2gbm: Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin

2gbn: Crystal Structure of the 35-36 8 Glycine Insertion Mutant of Ubiquitin

2gbr: Crystal Structure of the 35-36 MoaD Insertion Mutant of Ubiquitin

2gmi: Mms2/Ubc13~Ubiquitin

2hd5: USP2 in complex with ubiquitin

2hth: Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain

2ibi: Covalent Ubiquitin-USP2 Complex

2j7q: CRYSTAL STRUCTURE OF THE UBIQUITIN-SPECIFIC PROTEASE ENCODED BY MURINE CYTOMEGALOVIRUS TEGUMENT PROTEIN M48 IN COMPLEX WITH A UBQUITIN-BASED SUICIDE SUBSTRATE

2nr2: The MUMO (minimal under-restraining minimal over-restraining) method for the determination of native states ensembles of proteins

2o6v: Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH

2oob: crystal structure of the UBA domain from Cbl-b ubiquitin ligase in complex with ubiquitin

Ubiquitin A-52 residue ribosomal protein fusion product 1

References

Further reading