USP4
Ubiquitin carboxyl-terminal hydrolase 4 is an enzyme that in humans is encoded by the USP4 gene.[1][2][3] This protein is a member of cysteine peptidase family C19.
Interactions
USP4 has been shown to interact with Retinoblastoma protein.[4]
References
- ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346.
- ^ Frederick A, Rolfe M, Chiu MI (Feb 1998). "The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines". Oncogene 16 (2): 153–165. doi:10.1038/sj.onc.1201537. PMID 9464533.
- ^ "Entrez Gene: USP4 ubiquitin specific peptidase 4 (proto-oncogene)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7375.
- ^ Blanchette, P; Gilchrist C A, Baker R T, Gray D A (Sep. 2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130". Oncogene (England) 20 (39): 5533–5537. doi:10.1038/sj.onc.1204823. ISSN 0950-9232. PMID 11571651.
Further reading
- D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–352. doi:10.1080/10409239891204251. PMID 9827704.
- Gray DA, Inazawa J, Gupta K et al. (1995). "Elevated expression of Unph, a proto-oncogene at 3p21.3, in human lung tumors". Oncogene 10 (11): 2179–83. PMID 7784062.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Gupta K, Chevrette M, Gray DA (1994). "The Unp proto-oncogene encodes a nuclear protein". Oncogene 9 (6): 1729–31. PMID 8183569.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Di Donato F, Chan EK, Askanase AD et al. (2001). "Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function". Int. J. Biochem. Cell Biol. 33 (9): 924–934. doi:10.1016/S1357-2725(01)00055-3. PMID 11461834.
- Blanchette P, Gilchrist CA, Baker RT, Gray DA (2001). "Association of UNP, a ubiquitin-specific protease, with the pocket proteins pRb, p107 and p130". Oncogene 20 (39): 5533–5537. doi:10.1038/sj.onc.1204823. PMID 11571651.
- DeSalle LM, Latres E, Lin D et al. (2001). "The de-ubiquitinating enzyme Unp interacts with the retinoblastoma protein". Oncogene 20 (39): 5538–5542. doi:10.1038/sj.onc.1204824. PMID 11571652.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Wada K, Tanji K, Kamitani T (2006). "Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its isopeptidase activity". Biochem. Biophys. Res. Commun. 339 (3): 731–736. doi:10.1016/j.bbrc.2005.11.076. PMID 16316627.
- Wada K, Kamitani T (2006). "UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself". Biochem. Biophys. Res. Commun. 342 (1): 253–258. doi:10.1016/j.bbrc.2006.01.144. PMID 16472766.