USP33

Ubiquitin specific peptidase 33

PDB rendering based on 2uzg.

Available structures
PDB	2uzg

Identifiers

Symbols

USP33; KIAA1097; MGC16868; VDU1

External IDs

MGI: 2159711 HomoloGene: 8996 GeneCards: USP33 Gene

EC number

3.4.19.12

Gene Ontology
Molecular function	• G-protein-coupled receptor binding • cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • ubiquitin-specific protease activity • protein binding • peptidase activity • zinc ion binding • ubiquitin binding • metal ion binding
Cellular component	• cytoplasm • VCB complex • perinuclear region of cytoplasm
Biological process	• ubiquitin-dependent protein catabolic process • endocytosis • axon guidance • regulation of G-protein coupled receptor protein signaling pathway • cell migration • protein deubiquitination • protein K63-linked deubiquitination • protein K48-linked deubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
78.16 – 78.23 Mb

Chr 3:
152.01 – 152.06 Mb

PubMed search

[1]

[2]

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.^[1]^[2]

Interactions

USP33 has been shown to interact with DIO2,^[3] SELENBP1^[4] and Von Hippel-Lindau tumor suppressor.^[5]

References

^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346.
^ "Entrez Gene: USP33 ubiquitin specific peptidase 33". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23032.
^ Curcio-Morelli, Cyntia; Zavacki Ann Marie, Christofollete Marcelo, Gereben Balazs, de Freitas Beatriz C G, Harney John W, Li Zaibo, Wu Guan, Bianco Antonio C (Jul. 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. (United States) 112 (2): 189–196. doi:10.1172/JCI18348. ISSN 0021-9738. PMC 164294. PMID 12865408. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164294.
^ Jeong, Jee-Yeong; Wang Yuxun, Sytkowski Arthur J (Feb. 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. (United States) 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533.
^ Li, Zaibo; Na Xi, Wang Dakun, Schoen Susan R, Messing Edward M, Wu Guan (Feb. 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. (United States) 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. ISSN 0021-9258. PMID 11739384.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Kikuno R, Nagase T, Ishikawa K et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
Li Z, Na X, Wang D et al. (2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384.
Li Z, Wang D, Na X et al. (2002). "Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor". Biochem. Biophys. Res. Commun. 294 (3): 700–709. doi:10.1016/S0006-291X(02)00534-X. PMID 12056827.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Curcio-Morelli C, Zavacki AM, Christofollete M et al. (2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164294.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Allen MD, Bycroft M (2007). "The solution structure of the ZnF UBP domain of USP33/VDU1". Protein Sci. 16 (9): 2072–2075. doi:10.1110/ps.072967807. PMC 2206988. PMID 17766394. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2206988.

PDB gallery

USP33

Interactions

References

Further reading