UQCRH

Ubiquinol-cytochrome c reductase hinge protein

PDB rendering based on 1bcc.

Available structures
PDB	1bcc, 1be3, 1bgy, 1l0l, 1l0n, 1ntk, 1ntm, 1ntz, 1nu1, 1pp9, 1ppj, 1qcr, 1sqb, 1sqp, 1sqq, 1sqv, 1sqx, 2a06, 2bcc, 2fyu, 3bcc

Identifiers

Symbols

UQCRH; MGC111572; QCR6; UQCR8

External IDs

OMIM: 613844 MGI: 1913826 HomoloGene: 104063 GeneCards: UQCRH Gene

EC number

1.10.2.2

Gene Ontology
Molecular function	• ubiquinol-cytochrome-c reductase activity • protein complex binding
Cellular component	• mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain • mitochondrial respiratory chain complex III • membrane
Biological process	• oxidative phosphorylation • mitochondrial electron transport, ubiquinol to cytochrome c • transport • aerobic respiration • respiratory electron transport chain • protein heterooligomerization • oxidation-reduction process

Orthologs

Species

Human

Mouse

n/a

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

n/a

Chr 4:
115.56 – 115.57 Mb

PubMed search

[1]

[2]

Cytochrome b-c1 complex subunit 6, mitochondrial is a protein that in humans is encoded by the UQCRH gene.^[1]^[2]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex; E.C. 1.10.2.2), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and "Rieske-associated protein".

References

^ Ohta S, Goto K, Arai H, Kagawa Y (Jan 1988). "An extremely acidic amino-terminal presequence of the precursor for the human mitochondrial hinge protein". FEBS Lett 226 (1): 171–5. doi:10.1016/0014-5793(87)80573-2. PMID 2826252.
^ "Entrez Gene: UQCRH ubiquinol-cytochrome c reductase hinge protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7388.

Liu AY, Bradner RC (1993). "Elevated expression of the human mitochondrial hinge protein gene in cancer.". Cancer Res. 53 (11): 2460–5. PMID 7684318.
Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank.". Gene 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Modena P, Testi MA, Facchinetti F, et al. (2003). "UQCRH gene encoding mitochondrial Hinge protein is interrupted by a translocation in a soft-tissue sarcoma and epigenetically inactivated in some cancer cell lines". Oncogene 22 (29): 4586–93. doi:10.1038/sj.onc.1206472. PMID 12881716.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

PDB gallery

1bcc: CYTOCHROME BC1 COMPLEX FROM CHICKEN

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE

1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE

1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

1l0n: native structure of bovine mitochondrial cytochrome bc1 complex

1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1

1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom

1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)

1pp9: Bovine cytochrome bc1 complex with stigmatellin bound

1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin

1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY

1sqb: Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin

1sqp: Crystal Structure Analysis of Bovine Bc1 with Myxothiazol

1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)

1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT

1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A

2a06: Bovine cytochrome bc1 complex with stigmatellin bound

2bcc: STIGMATELLIN-BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

3bcc: STIGMATELLIN AND ANTIMYCIN BOUND CYTOCHROME BC1 COMPLEX FROM CHICKEN

UQCRH

References

Further reading